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Blyth E, Withers B, Clancy L, et al. CMV-specific immune reconstitution following allogeneic stem cell transplantation. Virulence. 2016;7(8):967-980doi: 10.1080/21505594.2016.1221022.
Blyth, E., Withers, B., Clancy, L., & Gottlieb, D. (2016). CMV-specific immune reconstitution following allogeneic stem cell transplantation. Virulence, 7(8), 967-980. https://doi.org/10.1080/21505594.2016.1221022
Blyth, Emily, et al. "CMV-specific immune reconstitution following allogeneic stem cell transplantation." Virulence vol. 7,8 (2016): 967-980. doi: https://doi.org/10.1080/21505594.2016.1221022
Blyth E, Withers B, Clancy L, Gottlieb D. CMV-specific immune reconstitution following allogeneic stem cell transplantation. Virulence. 2016 Nov 16;7(8):967-980. doi: 10.1080/21505594.2016.1221022. Epub 2016 Aug 09. PMID: 27580355; PMCID: PMC5160403.
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Virulence. 2016 Nov 16;7(8):967-980. doi: 10.1080/21505594.2016.1221022. Epub 2016 Aug 09.

CMV-specific immune reconstitution following allogeneic stem cell transplantation.

Virulence

Emily Blyth, Barbara Withers, Leighton Clancy, David Gottlieb

Affiliations

  1. a Westmead Institute for Medical Research at the University of Sydney , Westmead , Sydney , Australia.
  2. b Blood and Marrow Transplant Unit, Westmead Hospital , Sydney , Australia.
  3. c Department of Haematology , Westmead , Sydney , Australia.
  4. d Sydney Cellular Therapies Laboratory , Westmead , Sydney , Australia.

PMID: 27580355 PMCID: PMC5160403 DOI: 10.1080/21505594.2016.1221022

Abstract

Cytomegalovirus (CMV) remains a major contributor to morbidity and mortality following allogeneic haemopoietic stem cell transplant (HSCT) despite widespread use of viraemia monitoring and pre-emptive antiviral therapy. Uncontrolled viral replication occurs primarily in the first 100 d post transplant but this high risk period can extend to many months if immune recovery is delayed. The re-establishment of a functional population of cellular effectors is essential for control of virus replication and depends on recipient and donor serostatus, the stem cell source, degree of HLA matching and post-transplant factors such as CMV antigen exposure, presence of GVHD and ongoing use of immune suppression. A number of immune monitoring assays exist but have not yet become widely accessible for routine clinical use. Vaccination, adoptive transfer of CMV specific T cells and a number of graft engineering processes are being evaluated to enhance of CMV specific immune recovery post HSCT.

Keywords: CMV immunity; Cytomegalovirus; adoptive T cell transfer; haemopoietic stem cell transplantation; immunotherapy

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