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Dekruyff RH, Cantor H, Dorf ME. Activation requirements of cloned inducer T cells. II. The failure of some clones to respond to antigen presented by activated B cells. J Immunol. 1986;136(2):446-51
Dekruyff, R. H., Cantor, H., & Dorf, M. E. (1986). Activation requirements of cloned inducer T cells. II. The failure of some clones to respond to antigen presented by activated B cells. Journal of immunology (Baltimore, Md. : 1950), 136(2), 446-51.
Dekruyff, R H, et al. "Activation requirements of cloned inducer T cells. II. The failure of some clones to respond to antigen presented by activated B cells." Journal of immunology (Baltimore, Md. : 1950) vol. 136,2 (1986): 446-51.
Dekruyff RH, Cantor H, Dorf ME. Activation requirements of cloned inducer T cells. II. The failure of some clones to respond to antigen presented by activated B cells. J Immunol. 1986 Jan;136(2):446-51. PMID: 3484492.
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J Immunol. 1986 Jan;136(2):446-51.

Activation requirements of cloned inducer T cells. II. The failure of some clones to respond to antigen presented by activated B cells.

Journal of immunology (Baltimore, Md. : 1950)

R H Dekruyff, H Cantor, M E Dorf

PMID: 3484492

Abstract

Inducer/helper T cells recognize nominal antigen in association with Ia on the surface of the antigen-presenting cell (APC). Recent studies have shown that B cells can effectively function as APC. In the present study we have assessed the ability of cloned inducer T cells to discriminate between activated B cells or splenic macrophages as APC. We found that most of the clones tested demonstrated an equivalent response to antigen presented by activated B cells or splenic adherent cells. Some clones were very efficiently stimulated by antigen presented by activated B cells, whereas other clones failed to respond or responded very poorly when activated B cells were used to present antigen. We attempted to determine the mechanism responsible for the inability of certain clones to proliferate in response to antigen presented by activated B cells.

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