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Bouquot JE, Weiland LH, Kurland LT. Leukoplakia and carcinoma in situ synchronously associated with invasive oral/oropharyngeal carcinoma in Rochester, Minn., 1935-1984. Oral Surg Oral Med Oral Pathol. 1988;65(2):199-207doi: 10.1016/0030-4220(88)90166-1.
Bouquot, J. E., Weiland, L. H., & Kurland, L. T. (1988). Leukoplakia and carcinoma in situ synchronously associated with invasive oral/oropharyngeal carcinoma in Rochester, Minn., 1935-1984. Oral surgery, oral medicine, and oral pathology, 65(2), 199-207. https://doi.org/10.1016/0030-4220(88)90166-1
Bouquot, J E, et al. "Leukoplakia and carcinoma in situ synchronously associated with invasive oral/oropharyngeal carcinoma in Rochester, Minn., 1935-1984." Oral surgery, oral medicine, and oral pathology vol. 65,2 (1988): 199-207. doi: https://doi.org/10.1016/0030-4220(88)90166-1
Bouquot JE, Weiland LH, Kurland LT. Leukoplakia and carcinoma in situ synchronously associated with invasive oral/oropharyngeal carcinoma in Rochester, Minn., 1935-1984. Oral Surg Oral Med Oral Pathol. 1988 Feb;65(2):199-207. doi: 10.1016/0030-4220(88)90166-1. PMID: 3422724.
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Oral Surg Oral Med Oral Pathol. 1988 Feb;65(2):199-207. doi: 10.1016/0030-4220(88)90166-1.

Leukoplakia and carcinoma in situ synchronously associated with invasive oral/oropharyngeal carcinoma in Rochester, Minn., 1935-1984.

Oral surgery, oral medicine, and oral pathology

J E Bouquot, L H Weiland, L T Kurland

Affiliations

  1. Department of Oral Pathology, West Virginia University Medical Center, Morgantown 26506.

PMID: 3422724 DOI: 10.1016/0030-4220(88)90166-1

Abstract

Previous investigations into the association between oral/oropharyngeal carcinoma and clinical white patches (leukoplakia) have noted that the latter lesion is found adjacent to malignancies in 10% to 100% of all carcinomas of this site. This is an unacceptable variation in results and probably relates more to the referral biases inherent in hospital-based studies than to any other factor. The present population-based study, which is relatively free of selection bias, demonstrates that 62%, 36%, and 18% of invasive carcinomas of the labial vermilion, oral cavity proper, and oropharynx, respectively, have leukoplakia lesions of immediately adjacent mucosal surfaces. Only 7% of invasive carcinomas have juxtaposed carcinoma in situ, whereas another 2% have severe epithelial dysplasia. Mucosal carcinomas associated with leukoplakias appear to be smaller, more mature histologically, and more likely to be only superficially invasive; such carcinomas present with fewer metastases at diagnosis and provide a better prognosis than similar carcinomas not associated with leukoplakia.

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