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Ho B, Tillotson JA, Kincannon LC, et al. The fate of nitroguanidine in the rat. Fundam Appl Toxicol. 1988;10(3):453-8doi: 10.1016/0272-0590(88)90291-6.
Ho, B., Tillotson, J. A., Kincannon, L. C., Simboli, P. B., & Korte, D. W. (1988). The fate of nitroguanidine in the rat. Fundamental and applied toxicology : official journal of the Society of Toxicology, 10(3), 453-8. https://doi.org/10.1016/0272-0590(88)90291-6
Ho, B, et al. "The fate of nitroguanidine in the rat." Fundamental and applied toxicology : official journal of the Society of Toxicology vol. 10,3 (1988): 453-8. doi: https://doi.org/10.1016/0272-0590(88)90291-6
Ho B, Tillotson JA, Kincannon LC, Simboli PB, Korte DW. The fate of nitroguanidine in the rat. Fundam Appl Toxicol. 1988 Apr;10(3):453-8. doi: 10.1016/0272-0590(88)90291-6. PMID: 3371584.
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Fundam Appl Toxicol. 1988 Apr;10(3):453-8. doi: 10.1016/0272-0590(88)90291-6.

The fate of nitroguanidine in the rat.

Fundamental and applied toxicology : official journal of the Society of Toxicology

B Ho, J A Tillotson, L C Kincannon, P B Simboli, D W Korte

Affiliations

  1. Division of Toxicology, Letterman Army Institute of Research, Presidio of San Francisco, California 94129-6800.

PMID: 3371584 DOI: 10.1016/0272-0590(88)90291-6

Abstract

The metabolism and disposition of nitroguanidine (NG), a component of military propellants and munitions, were examined in the rat. Radiolabeled nitroguanidine [( 14C]NG) was administered orally at doses of 20 and 200 mg/kg and intravenously at a dose of 20 mg/kg. Regardless of the route of administration, the radiolabel was recovered quantitatively in the urine of all animals within 48 hr after dosing. Chromatographic analysis of the urine indicated that the [14C]NG was excreted unchanged; no radiolabel was found in the expired air, feces, or tissues of the treated animals. No sex differences were seen in the disposition of NG. The kinetics of [14C]NG in the blood of the dosed animals was followed. The elimination half-life of NG was on the order of 2 hr. The bioavailability of orally administered NG was 100%; the kinetics of NG in the blood was not dose dependent. Examination of tissues 1 hr after an oral dose of NG showed that NG was evenly distributed throughout the body. Nitroguanidine is a chemical of low toxicity (LD50 greater than 5 g/kg); it is quantitatively absorbed from the gastrointestinal tract, distributed throughout the body, and rapidly excreted in the urine.

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