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J Innate Immun. 2012;4(4):371-6. doi: 10.1159/000335239. Epub 2012 Mar 02.

Collagen VI encodes antimicrobial activity: novel innate host defense properties of the extracellular matrix.

Journal of innate immunity

Suado M Abdillahi, Selma Balvanović, Maria Baumgarten, Matthias Mörgelin

Affiliations

  1. Division of Infection Medicine, Department of Clinical Sciences, Biomedical Center, Lund University, Lund, Sweden.

PMID: 22398575 PMCID: PMC6741453 DOI: 10.1159/000335239

Abstract

Collagen type VI is a subepithelial extracellular matrix component in airways and an adhesive substrate for oral pathogens [Bober et al.: J Innate Immun 2010;2:160-166]. Here, we report that collagen VI displays a dose-dependent antimicrobial activity against group A, C, and G streptococci by membrane disruption in physiological conditions. The data disclose previously unrecognized aspects of the extracellular matrix in innate host defense.

Copyright © 2012 S. Karger AG, Basel.

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