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Taha MO, Simões MJ, Haddad MA, et al. l-Arginine supplementation protects against hepatic ischemia-reperfusion lesions in rabbits. Transplant Proc. 2009;41(3):816-9doi: 10.1016/j.transproceed.2009.02.050.
Taha, M. O., Simões, M. J., Haddad, M. A., Capelato, R. C., Budny, N., Matsumoto, A. H., Soares, P. C., Santos, W. M., Armeato, G. D., Araki, C. M., Gomes, J. S., Magalhães, K. G., Tersariol, I. L., Monteiro, H. P., Oliveira-Júnior, I. S., Oliveira, I., Jurkiewicz, A., & Caricati-Neto, A. (2009). l-Arginine supplementation protects against hepatic ischemia-reperfusion lesions in rabbits. Transplantation proceedings, 41(3), 816-9. https://doi.org/10.1016/j.transproceed.2009.02.050
Taha, M O, et al. "l-Arginine supplementation protects against hepatic ischemia-reperfusion lesions in rabbits." Transplantation proceedings vol. 41,3 (2009): 816-9. doi: https://doi.org/10.1016/j.transproceed.2009.02.050
Taha MO, Simões MJ, Haddad MA, Capelato RC, Budny N, Matsumoto AH, Soares PC, Santos WM, Armeato GD, Araki CM, Gomes JS, Magalhães KG, Tersariol IL, Monteiro HP, Oliveira-Júnior IS, Oliveira I, Jurkiewicz A, Caricati-Neto A. l-Arginine supplementation protects against hepatic ischemia-reperfusion lesions in rabbits. Transplant Proc. 2009 Apr;41(3):816-9. doi: 10.1016/j.transproceed.2009.02.050. PMID: 19376360.
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Transplant Proc. 2009 Apr;41(3):816-9. doi: 10.1016/j.transproceed.2009.02.050.

l-Arginine supplementation protects against hepatic ischemia-reperfusion lesions in rabbits.

Transplantation proceedings

M O Taha, M J Simões, M A Haddad, R C Capelato, N Budny, A H Matsumoto, P C M Soares, W M Santos, G D Armeato, C M Araki, J S M Gomes, K G Magalhães, I L S Tersariol, H P Monteiro, I S Oliveira-Júnior, I Oliveira, A Jurkiewicz, A Caricati-Neto

Affiliations

  1. Department of Surgery, Federal University of São Paulo, Escola Paulista de Medicina, São Paulo, Brazil. [email protected]

PMID: 19376360 DOI: 10.1016/j.transproceed.2009.02.050

Abstract

We evaluated the effects of a substrate in the biosynthesis of nitric oxide (NO)-l-arginine (LARG)-on hepatic lesions caused by ischemia/reperfusion (I/R) injury in rabbit livers. Rabbits were pretreated with LARG (150 mg/kg IV) or saline solution 0.9% (SS) before the hepatic I/R procedure. The effects of LARG on hepatic injury were evaluated before and after I/R. The warm hepatic I/R procedure produced profound acute liver injury, as indicated by elevated values of serum aspartate aminotransferase (AST), alanine aminotransferase (ALT), and lactic dehydrogenase (LDH), as well as a high apoptotic cell count. All changes were attenuated by treatment with LARG before the hepatic I/R procedure. These results suggested that LARG produced protective effects on hepatic I/R lesions. This protective effect of LARG was probably associated with blocking generation of superoxide anions during the hepatic I/R procedure.

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