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Bergman SA, Wynn RL, Myers DE, et al. Low dose naloxone enhances buprenorphine in a tooth pulp antinociceptive assay. Arch Int Pharmacodyn Ther. 1988;291:229-37
Bergman, S. A., Wynn, R. L., Myers, D. E., & Rudo, F. G. (1988). Low dose naloxone enhances buprenorphine in a tooth pulp antinociceptive assay. Archives internationales de pharmacodynamie et de therapie, 291229-37.
Bergman, S A, et al. "Low dose naloxone enhances buprenorphine in a tooth pulp antinociceptive assay." Archives internationales de pharmacodynamie et de therapie vol. 291 (1988): 229-37.
Bergman SA, Wynn RL, Myers DE, Rudo FG. Low dose naloxone enhances buprenorphine in a tooth pulp antinociceptive assay. Arch Int Pharmacodyn Ther. 1988 Jan-Feb;291:229-37. PMID: 3365064.
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Arch Int Pharmacodyn Ther. 1988 Jan-Feb;291:229-37.

Low dose naloxone enhances buprenorphine in a tooth pulp antinociceptive assay.

Archives internationales de pharmacodynamie et de therapie

S A Bergman, R L Wynn, D E Myers, F G Rudo

Affiliations

  1. Dept. of Oral and Maxillofacial Surgery, Dental School, University of Maryland, Baltimore 21201.

PMID: 3365064

Abstract

Low dose naloxone was reported to produce analgesia of long duration in patients who received buprenorphine. A rabbit tooth pulp antinociceptive model was utilized to evaluate a possible interaction of buprenorphine and naloxone. Naloxone (0.001 mg/kg i.v.) 210 min after buprenorphine (0.10 mg/kg i.v.) significantly increased the % MPE from 48 +/- 5% to 78 +/- 6%. This increased activity occurred within 90 min after naloxone injection and had a duration of 2 hr. Naloxone, 0.1 mg/kg, or saline 0.1 ml/kg did not increase nor reduce the buprenorphine antinociceptive effect. Naloxone alone (0.001 mg/kg) produced a peak antinociceptive effect of 43 +/- 14% MPE which was significantly greater than that of the saline control group. Using a graded dose response paradigm in the rabbit tooth pulp model, the graded dose response curve of buprenorphine was significantly shifted upwards after preadministration of 0.001 mg/kg naloxone. The slopes of both the ascending and descending limbs of the biphasic buprenorphine dose response curves were not significantly different. The peak % MPE achieved by buprenorphine in the presence of 0.001 mg/kg naloxone (62 +/- 8%) was significantly greater than the buprenorphine-saline control (23 +/- 4%). It appears that a low dose of naloxone produces antinociception which enhances that of buprenorphine.

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