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Mancia G, Di Rienzo M, Giannattasio C, et al. Early and late sympathetic activation in hypertension. Scand Cardiovasc J Suppl. 1998;47:9-14
Mancia, G., Di Rienzo, M., Giannattasio, C., Parati, G., & Grassi, G. (1998). Early and late sympathetic activation in hypertension. Scandinavian cardiovascular journal. Supplement, 479-14.
Mancia, G, et al. "Early and late sympathetic activation in hypertension." Scandinavian cardiovascular journal. Supplement vol. 47 (1998): 9-14.
Mancia G, Di Rienzo M, Giannattasio C, Parati G, Grassi G. Early and late sympathetic activation in hypertension. Scand Cardiovasc J Suppl. 1998;47:9-14. PMID: 9540128.
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Scand Cardiovasc J Suppl. 1998;47:9-14.

Early and late sympathetic activation in hypertension.

Scandinavian cardiovascular journal. Supplement

G Mancia, M Di Rienzo, C Giannattasio, G Parati, G Grassi

Affiliations

  1. Department of Internal Medicine, University of Milan, S. Gerardo dei Tintori Hospital, Monza, Italy.

PMID: 9540128

Abstract

In several experimental animal models of hypertension, sympathetic factors have been shown to be involved in the development and/or maintenance of high blood pressure. Although the information available on this issue in man is more scarce, recent evidence clearly indicates the participation of adrenergic mechanisms in the early and late phases of the hypertensive process. In addition, several cardiovascular risk factors frequently associated with hypertension, such as obesity, insulin-resistance, cigarette smoking, and the atherogenic process, are also characterized by alterations in sympathetic cardiovascular drive. This contributes to a further activation of the sympathetic nervous system thus favoring the development of the end organ damage (e.g. cardiac and vascular hypertrophy) associated with the hypertensive state.

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