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Solal-Céligny P, Benichou C, Boivin P, et al. Critères d'imputation d'une cytopénie granuleuse ou plaquettaire à un médicament. Résultats de réunions de consensus. [Criteria for assessing granulocytic or platelet cytopenia caused by drugs. Results of consensus meetings]. Nouv Rev Fr Hematol. 1987;29(4):265-70
Solal-Céligny, P., Benichou, C., Boivin, P., Castot, A., Coulombel, L., Danan, G., Degos, L., Evreux, J. C., Lagier, G., & Lavarenne, J. (1987). Critères d'imputation d'une cytopénie granuleuse ou plaquettaire à un médicament. Résultats de réunions de consensus. [Criteria for assessing granulocytic or platelet cytopenia caused by drugs. Results of consensus meetings]. Nouvelle revue francaise d'hematologie, 29(4), 265-70.
Solal-Céligny, P, et al. "Critères d'imputation d'une cytopénie granuleuse ou plaquettaire à un médicament. Résultats de réunions de consensus." [Criteria for assessing granulocytic or platelet cytopenia caused by drugs. Results of consensus meetings]. Nouvelle revue francaise d'hematologie vol. 29,4 (1987): 265-70.
Solal-Céligny P, Benichou C, Boivin P, Castot A, Coulombel L, Danan G, Degos L, Evreux JC, Lagier G, Lavarenne J. Critères d'imputation d'une cytopénie granuleuse ou plaquettaire à un médicament. Résultats de réunions de consensus. [Criteria for assessing granulocytic or platelet cytopenia caused by drugs. Results of consensus meetings]. Nouv Rev Fr Hematol. 1987;29(4):265-70. French. PMID: 3320952.
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Nouv Rev Fr Hematol. 1987;29(4):265-70.

[Criteria for assessing granulocytic or platelet cytopenia caused by drugs. Results of consensus meetings].

Nouvelle revue francaise d'hematologie

[Article in French]
P Solal-Céligny, C Benichou, P Boivin, A Castot, L Coulombel, G Danan, L Degos, J C Evreux, G Lagier, J Lavarenne

Affiliations

  1. Service d'Hématologie Clinique, Hôpital Beaujon, Clichy.

PMID: 3320952

Abstract

The use of an official drug adverse reaction assessment procedure became compulsory in France in 1984. The method proposed various qualifications for the semiologic and chronologic criteria used to ascribe a disorder to a specific drug but did not define them. Consensus meetings have been organized in order to define, in the main pathological fields, the adverse reactions themselves and the various qualifications of the criteria. This paper reports the results of meetings attended by hematologists, members of the French national network of Pharmacovigilance and representatives of Roussel Uclaf Drug Monitoring Department for drug-induced granulocyte and platelet cytopenias. Participants studied (a) the limits of the time interval between the appearance of the adverse reaction and the beginning or the end of the treatment with the suspected drug; (b) interpretation of a possible rechallenge; and (c) diagnostic value of in vitro tests proposed to confirm the responsibility of a specific drug in a granulocytic or platelet cytopenia.

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