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Berkman SA, Lee ML, Gale RP. Clinical uses of intravenous immunoglobulins. Semin Hematol. 1988;25(2):140-58
Berkman, S. A., Lee, M. L., & Gale, R. P. (1988). Clinical uses of intravenous immunoglobulins. Seminars in hematology, 25(2), 140-58.
Berkman, S A, et al. "Clinical uses of intravenous immunoglobulins." Seminars in hematology vol. 25,2 (1988): 140-58.
Berkman SA, Lee ML, Gale RP. Clinical uses of intravenous immunoglobulins. Semin Hematol. 1988 Apr;25(2):140-58. PMID: 3291131.
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Semin Hematol. 1988 Apr;25(2):140-58.

Clinical uses of intravenous immunoglobulins.

Seminars in hematology

S A Berkman, M L Lee, R P Gale

Affiliations

  1. Department of Medicine, University of California Los Angeles School of Medicine 90024.

PMID: 3291131

Abstract

Immunoglobulins are an important component of host defense against infections. They also play a central role in immune regulation. A wide spectrum of human diseases is associated with decreased or abnormal regulation of immunoglobulin levels. Recently IV preparations of immunoglobulin have become available for clinical studies. There are already substantial data indicating a useful role for IV immunoglobulin in patients with primary hypogammaglobulinemia, neonates predisposed to group B streptococcal infections, individuals with ITP, children with Kawasaki disease, and bone marrow transplant patients predisposed to CMV infections. Promising data have been reported in burn patients and in individuals with CLL; these data require confirmation. Potential areas for future investigation include AIDS, autoimmune disorders, and viral disorders other than CMV.

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