Invest Ophthalmol Vis Sci. 1988 Jul;29(7):1137-40.

Acute anterior uveitis and HLA-B27 subtypes.

Investigative ophthalmology & visual science

P J Derhaag, L P de Waal, A Linssen, T E Feltkamp

PMID: 3262094

Abstract

The tissue antigen HLA-B27 is found in 50% of Dutch acute anterior uveitis (AAU) patients. The prevalence of HLA-B27 in the normal population is only 8%. However, only approximately 1% of HLA-B27+ individuals will develop AAU. Therefore, it is possible that the disease is associated with a particular B27 subtype. We typed lymphocytes of 36 B27+ AAU patients, of which 20 also had ankylosing spondylitis, for three serologically defined B27 subtypes (B27 W, B27 K and B27 non W/non K). These subtypes were normally associated with AAU. The subtype frequencies in the patients suffering from both AAU and AS also showed no preference for a certain subtype. Subtype-specific characteristics of the primary structure of the various B27 subtype molecules therefore cannot be responsible for the disease association.

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Substances

• HLA Antigens
• HLA-B27 Antigen

MeSH terms

• Acute Disease
• Amino Acid Sequence
• Asians
• HLA Antigens / analysis
• HLA Antigens / classification
• HLA Antigens / genetics
• HLA-B27 Antigen
• Humans
• Molecular Sequence Data
• Spondylitis, Ankylosing / complications
• Uveitis, Anterior / complications
• Uveitis, Anterior / ethnology
• Uveitis, Anterior / immunology

Publication Types

• Journal Article
• Research Support, Non-U.S. Gov't

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