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Huet S, Raynal B, Degos L, et al. Implication des molécules HLA de classe I du monocyte lors de l'activation des cellules T par des anticorps monoclonaux CD2 ou CD3. [Implication of HLA class I molecule from monocyte in T-cell activation by CD2 or CD3 monoclonal antibodies]. C R Acad Sci III. 1987;304(18):469-72
Huet, S., Raynal, B., Degos, L., Boumsell, L., & Bernard, A. (1987). Implication des molécules HLA de classe I du monocyte lors de l'activation des cellules T par des anticorps monoclonaux CD2 ou CD3. [Implication of HLA class I molecule from monocyte in T-cell activation by CD2 or CD3 monoclonal antibodies]. Comptes rendus de l'Academie des sciences. Serie III, Sciences de la vie, 304(18), 469-72.
Huet, S, et al. "Implication des molécules HLA de classe I du monocyte lors de l'activation des cellules T par des anticorps monoclonaux CD2 ou CD3." [Implication of HLA class I molecule from monocyte in T-cell activation by CD2 or CD3 monoclonal antibodies]. Comptes rendus de l'Academie des sciences. Serie III, Sciences de la vie vol. 304,18 (1987): 469-72.
Huet S, Raynal B, Degos L, Boumsell L, Bernard A. Implication des molécules HLA de classe I du monocyte lors de l'activation des cellules T par des anticorps monoclonaux CD2 ou CD3. [Implication of HLA class I molecule from monocyte in T-cell activation by CD2 or CD3 monoclonal antibodies]. C R Acad Sci III. 1987;304(18):469-72. French. PMID: 3107765.
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C R Acad Sci III. 1987;304(18):469-72.

[Implication of HLA class I molecule from monocyte in T-cell activation by CD2 or CD3 monoclonal antibodies].

Comptes rendus de l'Academie des sciences. Serie III, Sciences de la vie

[Article in French]
S Huet, B Raynal, L Degos, L Boumsell, A Bernard

PMID: 3107765

Abstract

The role of monocytes in human T-cell activation by monoclonal antibodies (mAb) recognizing CD3 molecule or by 2 mAb pairs directed against different epitopes of CD2 "GT2+T11(1)" or "D66+T11(1)" has been studied. It appears that HLA-cl I molecules from monocytes are involved in the early activation phase of T-cells stimulated by CD3 or CD2 when direct contacts between T-cells and monocytes are required. Thus, pretreatment of monocytes with HLA-cl I mAb inhibited IL 2 receptor appearance and IL 2 synthesis on T-cells stimulated by CD3 mAb or CD2 "GT2+T11(1)" mAb pair.

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