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Sarma S, Howden E, Lawley J, et al. Central Command and the Regulation of Exercise Heart Rate Response in Heart Failure With Preserved Ejection Fraction. Circulation. 2020;143(8):783-789doi: 10.1161/CIRCULATIONAHA.120.048338.
Sarma, S., Howden, E., Lawley, J., Samels, M., & Levine, B. D. (2021). Central Command and the Regulation of Exercise Heart Rate Response in Heart Failure With Preserved Ejection Fraction. Circulation, 143(8), 783-789. https://doi.org/10.1161/CIRCULATIONAHA.120.048338
Sarma, Satyam, et al. "Central Command and the Regulation of Exercise Heart Rate Response in Heart Failure With Preserved Ejection Fraction." Circulation vol. 143,8 (2021): 783-789. doi: https://doi.org/10.1161/CIRCULATIONAHA.120.048338
Sarma S, Howden E, Lawley J, Samels M, Levine BD. Central Command and the Regulation of Exercise Heart Rate Response in Heart Failure With Preserved Ejection Fraction. Circulation. 2021 Feb 23;143(8):783-789. doi: 10.1161/CIRCULATIONAHA.120.048338. Epub 2020 Nov 18. PMID: 33205661; PMCID: PMC7902416.
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Circulation. 2021 Feb 23;143(8):783-789. doi: 10.1161/CIRCULATIONAHA.120.048338. Epub 2020 Nov 18.

Central Command and the Regulation of Exercise Heart Rate Response in Heart Failure With Preserved Ejection Fraction.

Circulation

Satyam Sarma, Erin Howden, Justin Lawley, Mitchel Samels, Benjamin D Levine

Affiliations

  1. Institute for Exercise and Environmental Medicine, Texas Health Presbyterian Hospital, Dallas (S.S., M.S., B.D.L.).
  2. Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas (S.S., B.D.L.).
  3. Baker Heart and Diabetes Institute, Melbourne, Australia (E.H.).
  4. Department of Sport Science, University of Innsbruck, Austria (J.L.).

PMID: 33205661 PMCID: PMC7902416 DOI: 10.1161/CIRCULATIONAHA.120.048338

Abstract

BACKGROUND: Chronotropic incompetence is common in heart failure with preserved ejection fraction (HFpEF) and is linked to impaired aerobic capacity. Whether upstream autonomic signaling pathways responsible for raising exercise heart rate are impaired in HFpEF is unknown. We investigated the integrity of central command and muscle metaboreceptor function, 2 predominant mechanisms responsible for exertional increases in heart rate, in patients with HFpEF and senior controls.

METHODS: Fourteen healthy senior controls (7 men, 7 women) and 20 carefully screened patients with HFpEF (8 men, 12 women) underwent cardiopulmonary exercise testing (peak Vo

RESULTS: Peak Vo

CONCLUSIONS: Central command (vagally mediated) and metaboreceptor function (sympathetically mediated) in patients with HFpEF were not different from those in healthy senior controls despite significantly lower peak whole-body exercise heart rates. These results demonstrate key reflex autonomic pathways regulating exercise heart rate responsiveness are intact in HFpEF.

Keywords: exercise; heart failure; heart rate

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