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Pearson AD, Mills S, Amineddine HA, et al. Pharmacokinetics of oral and intramuscular methotrexate in children with acute lymphoblastic leukaemia. Cancer Chemother Pharmacol. 1987;20(3):243-7doi: 10.1007/BF00570494.
Pearson, A. D., Mills, S., Amineddine, H. A., Long, D. R., Craft, A. W., & Chessells, J. M. (1987). Pharmacokinetics of oral and intramuscular methotrexate in children with acute lymphoblastic leukaemia. Cancer chemotherapy and pharmacology, 20(3), 243-7. https://doi.org/10.1007/BF00570494
Pearson, A D, et al. "Pharmacokinetics of oral and intramuscular methotrexate in children with acute lymphoblastic leukaemia." Cancer chemotherapy and pharmacology vol. 20,3 (1987): 243-7. doi: https://doi.org/10.1007/BF00570494
Pearson AD, Mills S, Amineddine HA, Long DR, Craft AW, Chessells JM. Pharmacokinetics of oral and intramuscular methotrexate in children with acute lymphoblastic leukaemia. Cancer Chemother Pharmacol. 1987;20(3):243-7. doi: 10.1007/BF00570494. PMID: 3315283.
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Cancer Chemother Pharmacol. 1987;20(3):243-7. doi: 10.1007/BF00570494.

Pharmacokinetics of oral and intramuscular methotrexate in children with acute lymphoblastic leukaemia.

Cancer chemotherapy and pharmacology

A D Pearson, S Mills, H A Amineddine, D R Long, A W Craft, J M Chessells

Affiliations

  1. Department of Child Health, University of Newcastle upon Tyne, England.

PMID: 3315283 DOI: 10.1007/BF00570494

Abstract

Repeated methotrexate absorption studies were performed under standard conditions in 127 children receiving either oral or intramuscular methotrexate for acute lymphoblastic leukaemia. There was marked variability in peak concentration, area under the serum concentration curve and clearance both between patients and in repeated studies on the same patient. Although the intramuscular route produced higher serum concentrations and AUC than the oral route, variability within and between patients was considerable and was most marked at higher concentrations. Neither age or sex could account for variation in methotrexate absorption or clearance. Intramuscular methotrexate, although producing higher serum concentrations and AUC, does not reduce the variability observed with oral administration. Prediction of subsequent methotrexate concentrations from the knowledge of one absorption profile is not possible.

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