Display options
Share it on

Circ Heart Fail. 2021 Nov;14(11):e008459. doi: 10.1161/CIRCHEARTFAILURE.121.008459. Epub 2021 Oct 29.

Prognostic Value of Elevated Levels of Plasma N-Acetylneuraminic Acid in Patients With Heart Failure.

Circulation. Heart failure

Chenze Li, Mingming Zhao, Lei Xiao, Haoran Wei, Zheng Wen, Dong Hu, Bo Yu, Yang Sun, Jianing Gao, Xiaoqing Shen, Qi Zhang, Huanhuan Cao, Jin Huang, Wei Huang, Ke Li, Man Huang, Li Ni, Ting Yu, Liang Ji, Yangkai Xu, Gang Liu, Matthew C Konerman, Lemin Zheng, Dao Wen Wang

Affiliations

  1. Department of Cardiology, Zhongnan Hospital of Wuhan University, Institute of Myocardial Injury and Repair, Wuhan University, China (C.L.).
  2. Division of Cardiology, Department of Internal Medicine and Hubei Key Laboratory of Genetics and Molecular Mechanisms of Cardiological Disorders, Tongji Hospital (C.L., L.X., H.W., Z.W., D.H., B.Y., Y.S., X.S., J.H., K.L., M.H., L.N., T.Y., D.W.W.), Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
  3. Department of Cardiology and Institute of Vascular Medicine, Peking University Third Hospital, NHC Key Laboratory of Cardiovascular Molecular Biology and Regulatory Peptides, Beijing Key Laboratory of Cardiovascular Receptors Research, Beijing, China (M.Z.).
  4. The Institute of Cardiovascular Sciences, Peking University, Key Laboratory of Molecular Cardiovascular Science, Ministry of Education, Beijing, China (M.Z., J.G., Q.Z., H.C., L.J., Y.X., L.Z.).
  5. Department of Cardiology, Central Theater General Hospital of the Chinese People's Liberation Army, Wuhan, China (W.H.).
  6. Department of Nutrition and Food Hygiene, Hubei Key Laboratory of Food Nutrition and Safety, Ministry of Education Key Lab of Environment and Health, School of Public Health (G.L.), Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
  7. Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Institute for Health Care Policy and Innovation, University of Michigan, Veterans Affairs Center for Clinical Management Research, Ann Arbor (M.C.K.).
  8. China National Clinical Research Center for Neurological Diseases, Tiantan Hospital, Advanced Innovation Center for Human Brain Protection, The Capital Medical University, Beijing (L.Z.).

PMID: 34711067 DOI: 10.1161/CIRCHEARTFAILURE.121.008459

Abstract

BACKGROUND: Cardiac sialylation is involved in a variety of physiological processes in the heart. Altered sialylation has been implicated in heart failure (HF) mice. However, its role in patients with HF is unclear, and the potential effect of modulation of cardiac sialylation is worth exploring.

METHODS: We first assessed the association between plasma N-acetylneuraminic acid levels and the incidence of adverse cardiovascular events in patients with HF over a median follow-up period of 2 years. Next, immunoblot analysis and lectin histochemistry were performed in cardiac tissue to determine the expression levels of neuraminidases and the extent of cardiac desialylation. Finally, the therapeutic impact of a neuraminidase inhibitor was evaluated in animal models of HF.

RESULTS: Among 1699 patients with HF, 464 (27%) died of cardiovascular-related deaths or underwent heart transplantation. We found that the elevated plasma N-acetylneuraminic acid level was independently associated with a higher risk of incident cardiovascular death and heart transplantation (third tertile adjusted hazard ratio, 2.11 [95% CI, 1.67-2.66],

CONCLUSIONS: This study uncovered a significant association between elevated plasma N-acetylneuraminic acid level and an increased risk of a poor clinical outcome in patients with HF. Our data support the notion that desialylation represents an important contributor to the progression of HF, and neuraminidase inhibition may be a potential therapeutic strategy for HF.

Keywords: N-acetylneuraminic acid; heart failure; neuraminidase; prognosis; risk

Substances

MeSH terms

Publication Types