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Iwai M, Kashiwadani M, Okuno T, et al. Cholestatic liver disease in a 20-yr-old woman with histiocytosis X. Am J Gastroenterol. 1988;83(2):164-8
Iwai, M., Kashiwadani, M., Okuno, T., Takino, T., & Koshikawa, T. (1988). Cholestatic liver disease in a 20-yr-old woman with histiocytosis X. The American journal of gastroenterology, 83(2), 164-8.
Iwai, M, et al. "Cholestatic liver disease in a 20-yr-old woman with histiocytosis X." The American journal of gastroenterology vol. 83,2 (1988): 164-8.
Iwai M, Kashiwadani M, Okuno T, Takino T, Koshikawa T. Cholestatic liver disease in a 20-yr-old woman with histiocytosis X. Am J Gastroenterol. 1988 Feb;83(2):164-8. PMID: 3257640.
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Am J Gastroenterol. 1988 Feb;83(2):164-8.

Cholestatic liver disease in a 20-yr-old woman with histiocytosis X.

The American journal of gastroenterology

M Iwai, M Kashiwadani, T Okuno, T Takino, T Koshikawa

Affiliations

  1. Third Department of Internal Medicine, Kyoto Prefectural University of Medicine, Japan.

PMID: 3257640

Abstract

A 20-yr-old woman with known diabetes insipidus complained of high fever and jaundice. Liver specimens biopsied under peritoneoscopy showed proliferating histiocytic or foamy cells in periportal areas. Immunocytochemical investigation demonstrated the presence of S-100 protein, but the absence of lysozyme in their histiocytic cells, and ultrastructural study revealed Birbeck granules in them. Vinblastine therapy reduced jaundice and high fever, and diabetes insipidus was controlled. Clinical, immunohistological, and cytological features suggested Letter-Siwe disease with jaundice, which responded well to treatment.

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