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Ito Y, Ando K, Noda H, et al. Evidence for increased sympatho-adrenomedullary activity in young subjects with borderline hypertension. Jpn Circ J. 1988;52(11):1326-34doi: 10.1253/jcj.52.1326.
Ito, Y., Ando, K., Noda, H., & Fujita, T. (1988). Evidence for increased sympatho-adrenomedullary activity in young subjects with borderline hypertension. Japanese circulation journal, 52(11), 1326-34. https://doi.org/10.1253/jcj.52.1326
Ito, Y, et al. "Evidence for increased sympatho-adrenomedullary activity in young subjects with borderline hypertension." Japanese circulation journal vol. 52,11 (1988): 1326-34. doi: https://doi.org/10.1253/jcj.52.1326
Ito Y, Ando K, Noda H, Fujita T. Evidence for increased sympatho-adrenomedullary activity in young subjects with borderline hypertension. Jpn Circ J. 1988 Nov;52(11):1326-34. doi: 10.1253/jcj.52.1326. PMID: 3225899.
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Jpn Circ J. 1988 Nov;52(11):1326-34. doi: 10.1253/jcj.52.1326.

Evidence for increased sympatho-adrenomedullary activity in young subjects with borderline hypertension.

Japanese circulation journal

Y Ito, K Ando, H Noda, T Fujita

Affiliations

  1. Department of Internal Medicine, University of Tsukuba, Ibaraki, Japan.

PMID: 3225899 DOI: 10.1253/jcj.52.1326

Abstract

Three different studies were performed to estimate the sympatho-adrenomedullary activity in young subjects with borderline hypertension (BHT, n = 40), compared with age-matched normotensive subjects (NT, n = 24). In the first study, 23 BHT and 9 NT were subjected to isometric stress by maintaining handgrip at the 30% level of maximal voluntary contraction for 3 min. The response of plasma total catecholamines at the second and third min during the isometric exercise were greater in BHT than in NT (98.9 +/- 24.3 vs. 18.0 +/- 30.7 and 93.0 +/- 12.6 vs. 47.1 +/- 15.4 pg/ml, respectively, p less than 0.05). In the second study, the effects of intravenous glucagon injection (1 USP unit) were studied in 12 BHT and 9 NT. The increments of plasma epinephrine (E) at 2 and 3 min after injection were significantly greater in BHT than those in NT: 44.1 +/- 12.3 vs. 5.1 +/- 4.4 pg/ml, and 68.9 +/- 13.2 vs 32.1 +/- 8.9 pg/ml, respectively, p less than 0.05. In the last study, the pressor effects of intravenous norepinephrine (NE) infusion (100 and 200 ng/kg/min for 15 min) were examined in 17 BHT and 15 NT under three different sodium balances: regular customary diet, treatment with diuretics and high-sodium diet. Treatment with diuretics decreased and high-sodium diet increased the pressor response to NE in both groups, but there were no significant differences in NE reactivity between 2 groups throughout the study.(ABSTRACT TRUNCATED AT 250 WORDS)

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