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Kardiologiia. 1988 Jan;28(1):66-70.

[Effect of captopril on arterial pressure, systemic hemodynamics and renin activity in the blood plasma of rats with spontaneous hypertension].

Kardiologiia

[Article in Russian]
V G Pinelis, T P Vakulina, M G Poliak, Kh M Markov

PMID: 3282117

Abstract

An angiotensin-I-converting enzyme, captopril, was administered since birth onward to normotensive (NR) and spontaneously hypertensive rats (SHR). It produced a marked hypotensive effect in SHR only. Cardiac output and circulating blood volume were similar in intact and experimental animals, NR and SHR alike. Captopril considerably increased plasma renin activity in NR and SHR.

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