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Hashiguchi Y, Okamura Y. The effect of cyclosporin A on the course of Paragonimus miyazakii infection in rats. J Helminthol. 1988;62(3):251-6doi: 10.1017/s0022149x00011615.
Hashiguchi, Y., & Okamura, Y. (1988). The effect of cyclosporin A on the course of Paragonimus miyazakii infection in rats. Journal of helminthology, 62(3), 251-6. https://doi.org/10.1017/s0022149x00011615
Hashiguchi, Y, and Okamura, Y. "The effect of cyclosporin A on the course of Paragonimus miyazakii infection in rats." Journal of helminthology vol. 62,3 (1988): 251-6. doi: https://doi.org/10.1017/s0022149x00011615
Hashiguchi Y, Okamura Y. The effect of cyclosporin A on the course of Paragonimus miyazakii infection in rats. J Helminthol. 1988 Sep;62(3):251-6. doi: 10.1017/s0022149x00011615. PMID: 3192918.
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J Helminthol. 1988 Sep;62(3):251-6. doi: 10.1017/s0022149x00011615.

The effect of cyclosporin A on the course of Paragonimus miyazakii infection in rats.

Journal of helminthology

Y Hashiguchi, Y Okamura

Affiliations

  1. Department of Parasitology, Kochi Medical School, Japan.

PMID: 3192918 DOI: 10.1017/s0022149x00011615

Abstract

The effect of the immunomodulatory fungal metabolite cyclosporin A (CyA) on the course of Paragonimus miyazakii infection in rats was studied. Administration of CyA 15 to 19 days post-infection resulted in a significantly lower recovery rate of worms and cyst formation in the host's lungs than in controls. Administration of CyA -1 to +3 days post-infection enhanced the growth and maturation of P. miyazakii, expressed as weight of worms and the number of worms with eggs in uteri with respect to control values. This study shows that administration of CyA to rats affects the host-parasite relationship, depending on the time of administration of the drug.

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