J Environ Sci Health B. 1988 Aug;23(4):409-26. doi: 10.1080/03601238809372615.

Deviations in hepatic amino acid profiles of mouse following repeated hexachlorophene administration.

Journal of environmental science and health. Part. B, Pesticides, food contaminants, and agricultural wastes

W Rajendra, G V Prasad, K Indira

PMID: 3192908 DOI: 10.1080/03601238809372615

Abstract

Effects of repeated administration of hexachlorophene (HCP) on the food consumption, body and liver weights, liver somatic indices and hepatic levels of the free amino acids and amino acid-enzyme activities have been studied. A dose-dependent reduction in body weights and food consumption and increased liver somatic indices suggested a progressive and on toward response to HCP. The concentrations of hepatic free amino acids: phenylalanine, tyrosine, leucine, isoleucine, valine, threonine, asparagine, glutamic acid and glutamine were significantly (p less than 0.001) increased while serine, glycine, taurine and alanine levels were unaffected. The aspartic acid levels showed a conspicuous decrement. The specific activity patterns of the amino acid-enzymes denoted reduced oxidation of amino acids in liver. The abnormal rise in branched chain and aromatic amino acids could be due to the reduced utilization because of the depletion of skeletal muscle mass and hepatic dysfunction in HCP intoxication. A pronounced reduction in aspartic acid levels may deserve consideration in the manifestation of hyperammonemia and neurologic symptoms in HCP intoxication.

Cited by

Substances

• Amino Acids
• Solvents
• Aspartate Aminotransferases
• Alanine Transaminase
• Hexachlorophene

MeSH terms

• Alanine Transaminase / analysis
• Amino Acids / analysis
• Animals
• Aspartate Aminotransferases / analysis
• Body Weight / drug effects
• Chromatography, High Pressure Liquid
• Eating / drug effects
• Hexachlorophene / administration & dosage
• Hexachlorophene / toxicity
• Liver / analysis
• Liver / drug effects
• Liver / enzymology
• Male
• Mice
• Organ Size / drug effects
• Solvents

Publication Types

• Journal Article
• Research Support, Non-U.S. Gov't

LinkOut - more resources

• Full Text Sources
  • Taylor & Francis
• Miscellaneous
  • NCI CPTAC Assay Portal