Display options
Cite
Martin RH. Meiotic segregation of human sperm chromosomes in translocation heterozygotes: report of a t(9;10)(q34;q11) and a review of the literature. Cytogenet Cell Genet. 1988;47(1):48-51doi: 10.1159/000132504.
Martin, R. H. (1988). Meiotic segregation of human sperm chromosomes in translocation heterozygotes: report of a t(9;10)(q34;q11) and a review of the literature. Cytogenetics and cell genetics, 47(1), 48-51. https://doi.org/10.1159/000132504
Martin, R H. "Meiotic segregation of human sperm chromosomes in translocation heterozygotes: report of a t(9;10)(q34;q11) and a review of the literature." Cytogenetics and cell genetics vol. 47,1 (1988): 48-51. doi: https://doi.org/10.1159/000132504
Martin RH. Meiotic segregation of human sperm chromosomes in translocation heterozygotes: report of a t(9;10)(q34;q11) and a review of the literature. Cytogenet Cell Genet. 1988;47(1):48-51. doi: 10.1159/000132504. PMID: 3281800.
Copy Download .nbib Format: NLM
Share it on

Cytogenet Cell Genet. 1988;47(1):48-51. doi: 10.1159/000132504.

Meiotic segregation of human sperm chromosomes in translocation heterozygotes: report of a t(9;10)(q34;q11) and a review of the literature.

Cytogenetics and cell genetics

R H Martin

Affiliations

  1. Department of Pediatrics, University of Calgary, Alberta, Canada.

PMID: 3281800 DOI: 10.1159/000132504

Abstract

Meiotic segregation products were studied in sperm from a man who was heterozygous for a reciprocal translocation, t(9;10)(q34;q11). A total of 171 sperm chromosome complements were studied by in vitro fertilization of hamster eggs. All possible 2:2 and 3:1 meiotic segregations were observed with the following frequencies: alternate, 41%; adjacent-1, 48%; adjacent-2, 5%; 3:1, 6%. Within alternate segregations, the number of normal sperm (35) was not significantly different from the number of sperm carrying a balanced form of the translocation (33), as expected. The proportion of sperm with an unbalanced form of the translocation was 60%. There was no evidence for an interchromosomal effect, since the frequencies of numerical (8%) and structural (15%) chromosomal abnormalities (both unrelated to the translocation) were within the normal range of control donors. The literature on a total of 10 translocation heterozygotes studied by sperm chromosome analysis was reviewed.

Cited by

MeSH terms

Publication Types