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Li P, Li F, Tang L, et al. Metabolic Profile in Neonatal Pig Hearts. Front Cardiovasc Med. 2021;8:763984doi: 10.3389/fcvm.2021.763984.
Li, P., Li, F., Tang, L., Zhang, W., Jin, Y., Gu, H., & Zhu, W. (2021). Metabolic Profile in Neonatal Pig Hearts. Frontiers in cardiovascular medicine, 8763984. https://doi.org/10.3389/fcvm.2021.763984
Li, Pengsheng, et al. "Metabolic Profile in Neonatal Pig Hearts." Frontiers in cardiovascular medicine vol. 8 (2021): 763984. doi: https://doi.org/10.3389/fcvm.2021.763984
Li P, Li F, Tang L, Zhang W, Jin Y, Gu H, Zhu W. Metabolic Profile in Neonatal Pig Hearts. Front Cardiovasc Med. 2021 Oct 14;8:763984. doi: 10.3389/fcvm.2021.763984. eCollection 2021. PMID: 34722687; PMCID: PMC8551694.
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Front Cardiovasc Med. 2021 Oct 14;8:763984. doi: 10.3389/fcvm.2021.763984. eCollection 2021.

Metabolic Profile in Neonatal Pig Hearts.

Frontiers in cardiovascular medicine

Pengsheng Li, Fan Li, Ling Tang, Wenjing Zhang, Yan Jin, Haiwei Gu, Wuqiang Zhu

Affiliations

  1. Department of Cardiovascular Diseases, Physiology and Biomedical Engineering, Center for Regenerative Medicine, Mayo Clinic Arizona, Scottsdale, AZ, United States.
  2. Laboratory of Regenerative Medicine in Sports Science, School of Physical Education and Sports Science, South China Normal University, Guangzhou, China.
  3. College of Health Solutions, Arizona State University, Phoenix, AZ, United States.
  4. Department of Environmental Health Sciences, Robert Stempel College of Public Health and Social Work, Florida International University, Miami, FL, United States.
  5. Department of Cellular Biology and Pharmacology, Herbert Wertheim College of Medicine, Center for Translational Science, Florida International University, Port St. Lucie, FL, United States.

PMID: 34722687 PMCID: PMC8551694 DOI: 10.3389/fcvm.2021.763984

Abstract

We evaluated the metabolic profile in pig hearts at postnatal day 1, 3, 7, and 28 (P1, P3, P7, and P28, respectively) using a targeted liquid chromatography tandem mass spectrometry assay. Our data showed that there is a clear separation of the detected metabolites in P1 vs. P28 hearts. Active anabolisms of nucleotide and proteins were observed in P1 hearts when cardiomyocytes retain high cell cycle activity. However, the active posttranslational protein modification, metabolic switch from glucose to fatty acids, and the reduced ratio of collagen to total protein were observed in P28 hearts when cardiomyocytes withdraw from cell cycle.

Copyright © 2021 Li, Li, Tang, Zhang, Jin, Gu and Zhu.

Keywords: heart; metabolism; metabolomics; neonatal; pig

Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

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