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Yamaguchi S, Matsumoto K, Wang W, et al. Differential Antihypertensive Effects of Oral Doses of Acetylcholine between Spontaneously Hypertensive Rats and Normotensive Rats. Foods. 2021;10(9)doi: 10.3390/foods10092107.
Yamaguchi, S., Matsumoto, K., Wang, W., & Nakamura, K. (2021). Differential Antihypertensive Effects of Oral Doses of Acetylcholine between Spontaneously Hypertensive Rats and Normotensive Rats. Foods (Basel, Switzerland), 10(9), . https://doi.org/10.3390/foods10092107
Yamaguchi, Shohei, et al. "Differential Antihypertensive Effects of Oral Doses of Acetylcholine between Spontaneously Hypertensive Rats and Normotensive Rats." Foods (Basel, Switzerland) vol. 10,9 (2021). doi: https://doi.org/10.3390/foods10092107
Yamaguchi S, Matsumoto K, Wang W, Nakamura K. Differential Antihypertensive Effects of Oral Doses of Acetylcholine between Spontaneously Hypertensive Rats and Normotensive Rats. Foods. 2021 Sep 06;10(9). doi: 10.3390/foods10092107. PMID: 34574216; PMCID: PMC8469729.
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Foods. 2021 Sep 06;10(9). doi: 10.3390/foods10092107.

Differential Antihypertensive Effects of Oral Doses of Acetylcholine between Spontaneously Hypertensive Rats and Normotensive Rats.

Foods (Basel, Switzerland)

Shohei Yamaguchi, Kento Matsumoto, Wenhao Wang, Kozo Nakamura

Affiliations

  1. Department of Science and Technology, Graduate School of Medicine, Science and Technology, Shinshu University, 8304, Minamiminowa, Nagano 399-4598, Japan.
  2. Itoen Co., Ltd., 21, Mekami, Makinohara, Shizuoka 421-0516, Japan.
  3. Institute of Agriculture, Academic Assembly, Shinshu University, 8304, Minamiminowa, Nagano 399-4598, Japan.

PMID: 34574216 PMCID: PMC8469729 DOI: 10.3390/foods10092107

Abstract

Acetylcholine (ACh) is a novel antihypertensive food component. Here, we demonstrate the differential effects of oral ACh on high and normal blood pressure in rats. Spontaneously hypertensive rats (SHRs) and Wistar-Kyoto (WKY) rats were administered ACh orally. The blood pressure and heart rate of SHRs were significantly lowered with ACh doses of 10

Keywords: Wistar–Kyoto rats; acetylcholine; blood pressure; functional food; spontaneously hypertensive rats

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