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Willcox BJ, Willcox DC, Todoriki H, et al. Caloric Restriction, Energy Balance and Healthy Aging in Okinawans and Americans: Biomarker Differences in Septuagenarians. Okinawan J Am Stud. 2007;4:60-72
Willcox, B. J., Willcox, D. C., Todoriki, H., Yano, K., Curb, J. D., & Suzuki, M. (2007). Caloric Restriction, Energy Balance and Healthy Aging in Okinawans and Americans: Biomarker Differences in Septuagenarians. The Okinawan journal of American studies, 460-72.
Willcox, Bradley J, et al. "Caloric Restriction, Energy Balance and Healthy Aging in Okinawans and Americans: Biomarker Differences in Septuagenarians." The Okinawan journal of American studies vol. 4 (2007): 60-72.
Willcox BJ, Willcox DC, Todoriki H, Yano K, Curb JD, Suzuki M. Caloric Restriction, Energy Balance and Healthy Aging in Okinawans and Americans: Biomarker Differences in Septuagenarians. Okinawan J Am Stud. 2007;4:60-72. PMID: 34629932; PMCID: PMC8496353.
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Okinawan J Am Stud. 2007;4:60-72.

Caloric Restriction, Energy Balance and Healthy Aging in Okinawans and Americans: Biomarker Differences in Septuagenarians.

The Okinawan journal of American studies

Bradley J Willcox, D Craig Willcox, Hidemi Todoriki, Katsuhiko Yano, J David Curb, Makoto Suzuki

Affiliations

  1. The institute where the work was conducted: Pacific Health Research Institute, University of Hawaii, Okinawa International University, University of the Ryukyus, Okinawa Research Center for Longevity Science.

PMID: 34629932 PMCID: PMC8496353

Abstract

BACKGROUND: Caloric restriction (CR) is the only consistently reproducible non-genetic means of minimizing age-related diseases and increasing maximum lifespan in short-lived animals but few human studies exist.

OBJECTIVE: Since elderly Okinawans exhibit several phenotypic features of CR including low BMI, low prevalence of chronic diseases, and exceptional longevity, we hypothesized that this phenotype may be reflected in candidate biomarkers of human aging.

METHODS: We retrospectively estimated adult energy balance across the life course for septuagenarian birth cohorts (born ca 1915-1925) from Okinawa and the U.S. based on archived data. We then compared plasma DHEA, estrogen and testosterone in a sample of community dwelling members from these birth cohorts.

RESULTS: Elderly Okinawans had much lower caloric intake than Americans and appeared mildly calorically restricted (10-15%) at younger ages relative to their estimated energy requirements. Okinawans also had significantly higher plasma DHEA, testosterone and estrogen levels as septuagenarians versus non-CR Americans of similar chronological age.

CONCLUSION: These cross-sectional data are consistent with the caloric restriction hypothesis in humans and support further longitudinal investigation into biomarkers of human aging and their potential modification by caloric restriction.

Keywords: Caloric restriction; DHEA; Okinawa; biomarker; human; longevity

References

  1. Eur J Endocrinol. 2003 Dec;149(6):583-9 - PubMed
  2. J Gerontol A Biol Sci Med Sci. 2004 Aug;59(8):789-95 - PubMed
  3. Cell. 2005 Feb 25;120(4):557-67 - PubMed
  4. J Gerontol A Biol Sci Med Sci. 2004 Jun;59(6):B560-7 - PubMed
  5. Nature. 1993 Nov 18;366(6452):215 - PubMed
  6. Proc Natl Acad Sci U S A. 2004 Apr 27;101(17):6659-63 - PubMed
  7. JAMA. 2006 Apr 5;295(13):1539-48 - PubMed
  8. Exp Gerontol. 2001 Jul;36(7):1025-34 - PubMed
  9. J Clin Endocrinol Metab. 1997 Jul;82(7):2093-6 - PubMed
  10. J Gerontol A Biol Sci Med Sci. 2004 May;59(5):405-7 - PubMed
  11. Menopause. 2002 Jan-Feb;9(1):23-31 - PubMed
  12. Aging Cell. 2004 Jun;3(3):87-95 - PubMed
  13. Circulation. 1992 Nov;86(5):1529-35 - PubMed
  14. Adv Data. 2004 Oct 27;(347):1-17 - PubMed
  15. J Am Geriatr Soc. 1998 Mar;46(3):391-2 - PubMed
  16. JAMA. 2007 Mar 7;297(9):986-94 - PubMed
  17. Exp Gerontol. 2004 Jun;39(6):897-902 - PubMed
  18. Exp Gerontol. 2003 Jan-Feb;38(1-2):35-46 - PubMed
  19. Nutrition. 1989 May-Jun;5(3):155-71; discussion 172 - PubMed
  20. J Gerontol A Biol Sci Med Sci. 2001 Mar;56 Spec No 1:7-19 - PubMed
  21. Steroids. 1998 May-Jun;63(5-6):322-8 - PubMed
  22. J Bone Miner Res. 1997 Nov;12(11):1833-43 - PubMed
  23. Prev Med. 1978 Jun;7(2):205-17 - PubMed
  24. Science. 2004 Sep 3;305(5689):1423-6 - PubMed
  25. Biogerontology. 2006 Jun;7(3):173-7 - PubMed
  26. J Am Diet Assoc. 1998 Apr;98(4):439-45 - PubMed
  27. J Gerontol A Biol Sci Med Sci. 2002 Jun;57(6):B211-24 - PubMed
  28. Womens Health Issues. 2004 Nov-Dec;14(6):212-9 - PubMed
  29. J Lab Clin Med. 1998 Apr;131(4):292-4 - PubMed
  30. J Lab Clin Med. 1998 Apr;131(4):316-23 - PubMed
  31. Metabolism. 1985 Aug;34(8):731-6 - PubMed
  32. J Am Coll Nutr. 1997 Jun;16(3):229-35 - PubMed
  33. J Biol Chem. 2005 Apr 22;280(16):16417-26 - PubMed
  34. Gerontology. 2005 Mar-Apr;51(2):73-82 - PubMed
  35. Tissue Antigens. 1997 Nov;50(5):489-93 - PubMed
  36. Lancet. 1987 Oct 10;2(8563):824-6 - PubMed
  37. Mech Ageing Dev. 2005 Sep;126(9):913-22 - PubMed
  38. Am J Clin Nutr. 2003 Sep;78(3):361-9 - PubMed
  39. Science. 2002 Aug 2;297(5582):811 - PubMed

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