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Jost N, Christ T, Magyar J. New Strategies for the Treatment of Atrial Fibrillation. Pharmaceuticals (Basel). 2021;14(9)doi: 10.3390/ph14090926.
Jost, N., Christ, T., & Magyar, J. (2021). New Strategies for the Treatment of Atrial Fibrillation. Pharmaceuticals (Basel, Switzerland), 14(9), . https://doi.org/10.3390/ph14090926
Jost, Norbert, et al. "New Strategies for the Treatment of Atrial Fibrillation." Pharmaceuticals (Basel, Switzerland) vol. 14,9 (2021). doi: https://doi.org/10.3390/ph14090926
Jost N, Christ T, Magyar J. New Strategies for the Treatment of Atrial Fibrillation. Pharmaceuticals (Basel). 2021 Sep 15;14(9). doi: 10.3390/ph14090926. PMID: 34577626; PMCID: PMC8466466.
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Pharmaceuticals (Basel). 2021 Sep 15;14(9). doi: 10.3390/ph14090926.

New Strategies for the Treatment of Atrial Fibrillation.

Pharmaceuticals (Basel, Switzerland)

Norbert Jost, Torsten Christ, János Magyar

Affiliations

  1. Department of Pharmacology and Pharmacotherapy, Faculty of Medicine, University of Szeged, 6725 Szeged, Hungary.
  2. Department of Pharmacology and Pharmacotherapy, Interdisciplinary Excellence Centre, University of Szeged, 6725 Szeged, Hungary.
  3. ELKH-SZTE Research Group for Cardiovascular Pharmacology, Eötvös Loránd Research Network, 6725 Szeged, Hungary.
  4. Institute of Experimental Pharmacology and Toxicology, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany.
  5. DZHK (German Center for Cardiovascular Research), Partner Site Hamburg/Kiel/Lübeck, 20246 Hamburg, Germany.
  6. Department of Physiology, Faculty of Medicine, University of Debrecen, 4032 Debrecen, Hungary.
  7. Department of Sport Physiology, Faculty of Medicine, University of Debrecen, 4032 Debrecen, Hungary.

PMID: 34577626 PMCID: PMC8466466 DOI: 10.3390/ph14090926

Abstract

Atrial fibrillation (AF) is the most prevalent cardiac arrhythmia in the clinical practice. It significantly contributes to the morbidity and mortality of the elderly population. Over the past 25-30 years intense effort in basic research has advanced the understanding of the relationship between the pathophysiology of AF and atrial remodelling. Nowadays it is clear that the various forms of atrial remodelling (electrical, contractile and structural) play crucial role in initiating and maintaining the persistent and permanent types of AF. Unlike in ventricular fibrillation, in AF rapid ectopic firing originating from pulmonary veins and re-entry mechanism may induce and maintain (due to atrial remodelling) this complex cardiac arrhythmia. The present review presents and discusses in detail the latest knowledge on the role of remodelling in AF. Special attention is paid to novel concepts and pharmacological targets presumably relevant to the drug treatment of atrial fibrillation.

Keywords: antifibrillatory drugs; atrial electrical remodelling; atrial fibrillation; atrial fibrosis; investigational drugs

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