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Henry I, Bernheim A, Bernard M, et al. Mapping of a human fibrillar collagen gene, pro alpha 1 (XI) (COL11A1), to the p21 region of chromosome 1. Genomics. 1988;3(1):87-90doi: 10.1016/0888-7543(88)90165-6.
Henry, I., Bernheim, A., Bernard, M., van der Rest, M., Kimura, T., Jeanpierre, C., Barichard, F., Berger, R., Olsen, B. R., & Ramirez, F. (1988). Mapping of a human fibrillar collagen gene, pro alpha 1 (XI) (COL11A1), to the p21 region of chromosome 1. Genomics, 3(1), 87-90. https://doi.org/10.1016/0888-7543(88)90165-6
Henry, I, et al. "Mapping of a human fibrillar collagen gene, pro alpha 1 (XI) (COL11A1), to the p21 region of chromosome 1." Genomics vol. 3,1 (1988): 87-90. doi: https://doi.org/10.1016/0888-7543(88)90165-6
Henry I, Bernheim A, Bernard M, van der Rest M, Kimura T, Jeanpierre C, Barichard F, Berger R, Olsen BR, Ramirez F. Mapping of a human fibrillar collagen gene, pro alpha 1 (XI) (COL11A1), to the p21 region of chromosome 1. Genomics. 1988 Jul;3(1):87-90. doi: 10.1016/0888-7543(88)90165-6. PMID: 3220479.
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Genomics. 1988 Jul;3(1):87-90. doi: 10.1016/0888-7543(88)90165-6.

Mapping of a human fibrillar collagen gene, pro alpha 1 (XI) (COL11A1), to the p21 region of chromosome 1.

Genomics

I Henry, A Bernheim, M Bernard, M van der Rest, T Kimura, C Jeanpierre, F Barichard, R Berger, B R Olsen, F Ramirez

Affiliations

  1. INSERM U73, Genetique et Pathologie Foetale, Paris, France.

PMID: 3220479 DOI: 10.1016/0888-7543(88)90165-6

Abstract

Type XI collagen is a minor and poorly characterized structural component of cartilage. Recently, cDNA and genomic clones coding for the pro alpha 1 chain of human Type XI collagen, formerly 1 alpha collagen, have been isolated and fully characterized. Here we have used one such probe to establish the chromosomal localization of the pro alpha 1 (XI) collagen gene (COL11A1) by hybridization to filter-bound DNA isolated from flow-sorted chromosomes and by in situ hybridization on metaphase chromosomes. This combination of approaches has enabled us to locate COL1A11 in the p21 region of chromosome 1. This represents the first mapping of a Type XI collagen gene and the first assignment of a collagen locus to chromosome 1. These studies also provide additional evidence for the nearly uniform dispersion of the human fibrillar collagen genes in the human genome.

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