Ric Clin Lab. 1985 Jan-Mar;15(1):1-8. doi: 10.1007/BF03029155.
La Ricerca in clinica e in laboratorio
R S Geha
PMID: 3158061 DOI: 10.1007/BF03029155
Anti-idiotypic (anti-Id) antibodies are directed against antigenic determinants expressed by the antigen-binding region of the immunoglobulin molecules. Their interaction with antigen receptors on immune cells modulates the immune response. In man auto-anti-Id antibodies have been demonstrated. These antibodies not only participate in the regulation of the immune response, but can result in disease as in the case of acquired angioedema with B cell malignancy and possibly in autoimmune diseases. Anti-Id antibodies may be useful tools in cancer immunotherapy and in the production of vaccines.
