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Semmler W, Gademann G, Bachert-Baumann P, et al. Monitoring human tumor response to therapy by means of P-31 MR spectroscopy. Radiology. 1988;166(2):533-9doi: 10.1148/radiology.166.2.3336731.
Semmler, W., Gademann, G., Bachert-Baumann, P., Zabel, H. J., Lorenz, W. J., & van Kaick, G. (1988). Monitoring human tumor response to therapy by means of P-31 MR spectroscopy. Radiology, 166(2), 533-9. https://doi.org/10.1148/radiology.166.2.3336731
Semmler, W, et al. "Monitoring human tumor response to therapy by means of P-31 MR spectroscopy." Radiology vol. 166,2 (1988): 533-9. doi: https://doi.org/10.1148/radiology.166.2.3336731
Semmler W, Gademann G, Bachert-Baumann P, Zabel HJ, Lorenz WJ, van Kaick G. Monitoring human tumor response to therapy by means of P-31 MR spectroscopy. Radiology. 1988 Feb;166(2):533-9. doi: 10.1148/radiology.166.2.3336731. PMID: 3336731.
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Radiology. 1988 Feb;166(2):533-9. doi: 10.1148/radiology.166.2.3336731.

Monitoring human tumor response to therapy by means of P-31 MR spectroscopy.

Radiology

W Semmler, G Gademann, P Bachert-Baumann, H J Zabel, W J Lorenz, G van Kaick

Affiliations

  1. German Cancer Research Center, Institute of Nuclear Medicine, Heidelberg.

PMID: 3336731 DOI: 10.1148/radiology.166.2.3336731

Abstract

Tumors in 23 patients were studied by means of in vivo phosphorus-31 magnetic resonance (MR) spectroscopy. In five patients, the response to chemotherapy and radiation therapy was monitored in a long-term follow-up study. In one patient, the P-31 MR spectra were recorded during the infusion of chemotherapeutic drugs. In comparison with healthy muscle tissue of patients, the tumors showed elevated inorganic phosphate, phosphomonoester, and phosphodiester peaks and reduced creatine phosphate peaks, whereas the nucleoside 5'-triphosphate levels remained nearly unchanged. Tumor treatment resulted in changes in the ratio of the signal intensity value of creatine phosphate to that of inorganic phosphate and in the sum of these values. In an osteosarcoma, an initial response followed by renewed tumor growth was clearly indicated by changes in these parameters. In the short-term follow-up examination, slight spectral changes were observed during the infusion of chemotherapeutic drugs. Changes in the concentrations of phosphorus metabolites during therapy can therefore be monitored in human tumors by means of P-31 MR spectroscopy.

Cited by

van Houtum QQ, Mohamed Hoesein FFAA, Verhoeff JJJC, van Rossum PPSN, van Lindert AASR, van der Velden TTA, van der Kemp WWJM, Klomp DDWJ, Arteaga de Castro CCS.
NMR Biomed. 2021 May;34(5):e4204. doi: 10.1002/nbm.4204. Epub 2019 Nov 17.
PMID: 31736167

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