Display options
Share it on

C R Acad Sci III. 1986;303(11):445-7.

[Stimulation of human lymphocytes by phorbol acetate and a calcium ionophore induces an early transient expression of the c-fos oncogene followed by c-myc].

Comptes rendus de l'Academie des sciences. Serie III, Sciences de la vie

[Article in French]
A Pompidou, M Corral, P Michel, J Kruh, T Curran

PMID: 3096504

Abstract

After stimulation of human lymphocytes by 12-0 tetradecanoyl phorbol acetate (TPA) and by the calcium ionophore A23187 an early transient expression of proto-oncogene fos followed by an expression of c-myc is observed, as has been described in rodent fibroblast stimulated by growth factors. This observation suggests a direct role of protein Kinase C and of calcium flux an the induction of cellular oncogenes fos and myc that may be associated with the early steps of activation and proliferation of lymphocytes.

Substances

MeSH terms

Publication Types