Acta Endocrinol (Copenh). 1987 Jul;115(3):373-7. doi: 10.1530/acta.0.1150373.

Are Leydig cells of neural origin? Substance P-like immunoreactivity in human testicular tissue.

Acta endocrinologica

W Schulze, M S Davidoff, A F Holstein

PMID: 3303786 DOI: 10.1530/acta.0.1150373

Abstract

Using the immunocytochemical peroxidase-antiperoxidase method we observed strong and selective staining of Leydig cells after incubation of human testicular tissue with an antiserum against substance P and a slightly weaker immunoreactivity against methionine-enkephalin. These results indicate that the embryologic origin of Leydig cells may require reconsideration and also offer a new perspective for research upon the local control mechanisms of spermatogenesis.

Cited by

Substances

• Intercellular Signaling Peptides and Proteins
• Peptides
• substance P-like peptides
• Enkephalin, Methionine

MeSH terms

• Adult
• Aged
• Enkephalin, Methionine / metabolism
• Humans
• Immunoenzyme Techniques
• Intercellular Signaling Peptides and Proteins
• Leydig Cells / metabolism
• Male
• Peptides / metabolism
• Spermatogenesis
• Testis / cytology
• Testis / metabolism

Publication Types

• Journal Article
• Research Support, Non-U.S. Gov't