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Chae-Kim JJ, Roman R, Hawkins K, et al. Severe late-onset ovarian hyperstimulation syndrome presenting with liver dysfunction after in vitro fertilization: A case report. Case Rep Womens Health. 2021;31:e00332doi: 10.1016/j.crwh.2021.e00332.
Chae-Kim, J. J., Roman, R., Hawkins, K., & Gavrilova-Jordan, L. (2021). Severe late-onset ovarian hyperstimulation syndrome presenting with liver dysfunction after in vitro fertilization: A case report. Case reports in women's health, 31e00332. https://doi.org/10.1016/j.crwh.2021.e00332
Chae-Kim, Jennifer J, et al. "Severe late-onset ovarian hyperstimulation syndrome presenting with liver dysfunction after in vitro fertilization: A case report." Case reports in women's health vol. 31 (2021): e00332. doi: https://doi.org/10.1016/j.crwh.2021.e00332
Chae-Kim JJ, Roman R, Hawkins K, Gavrilova-Jordan L. Severe late-onset ovarian hyperstimulation syndrome presenting with liver dysfunction after in vitro fertilization: A case report. Case Rep Womens Health. 2021 Jun 04;31:e00332. doi: 10.1016/j.crwh.2021.e00332. eCollection 2021 Jul. PMID: 34159057; PMCID: PMC8196041.
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Case Rep Womens Health. 2021 Jun 04;31:e00332. doi: 10.1016/j.crwh.2021.e00332. eCollection 2021 Jul.

Severe late-onset ovarian hyperstimulation syndrome presenting with liver dysfunction after in vitro fertilization: A case report.

Case reports in women's health

Jennifer J Chae-Kim, Robert Roman, Kristina Hawkins, Larisa Gavrilova-Jordan

Affiliations

  1. Department of Obstetrics and Gynecology, Texas A&M College of Medicine, Baylor Scott & White Health, 2401 South 31 St, Temple, TX, USA.
  2. Division of Reproductive Endocrinology, Infertility, and Genetics, Department of Obstetrics and Gynecology, Medical College of Georgia at Augusta University, 1120 5 St, Augusta, GA, USA.
  3. Central Georgia Fertility at Navicent Health, 777 Hemlock Street, Macon, GA, USA.

PMID: 34159057 PMCID: PMC8196041 DOI: 10.1016/j.crwh.2021.e00332

Abstract

Ovarian hyperstimulation syndrome (OHSS) is a feared complication of controlled ovarian stimulation (COS) and can be associated with significant morbidity and mortality. Risk factors for OHSS include a history of OHSS, young age, low body mass index (BMI), polycystic ovary syndrome, elevated serum levels of anti-Müllerian hormone (AMH), large number of recruited follicles, elevated serum levels of estradiol, and higher gonadotropin doses during COS. However, OHSS may develop in patients with minimal risk factors. We present the case of a patient with minimal risk factors who developed severe late-onset OHSS in early pregnancy with liver dysfunction requiring hospitalization. After hospital discharge, her pregnancy resulted in a term live birth. We recommend that clinicians include OHSS in the differential diagnosis of elevated levels of liver enzymes in early pregnancy.

© 2021 Published by Elsevier B.V.

Keywords: Case report; Early pregnancy; Liver dysfunction; Ovarian hyperstimulation syndrome; Transaminitis

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