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Stoyell-Conti FF, Chabbra A, Puthentharayil J, et al. Chronic administration of pharmacological doses of angiotensin 1-7 and iodoangiotensin 1-7 has minimal effects on blood pressure, heart rate, and cognitive function of spontaneously hypertensive rats. Physiol Rep. 2021;9(7):e14812doi: 10.14814/phy2.14812.
Stoyell-Conti, F. F., Chabbra, A., Puthentharayil, J., Rigatto, K., & Speth, R. C. (2021). Chronic administration of pharmacological doses of angiotensin 1-7 and iodoangiotensin 1-7 has minimal effects on blood pressure, heart rate, and cognitive function of spontaneously hypertensive rats. Physiological reports, 9(7), e14812. https://doi.org/10.14814/phy2.14812
Stoyell-Conti, Filipe F, et al. "Chronic administration of pharmacological doses of angiotensin 1-7 and iodoangiotensin 1-7 has minimal effects on blood pressure, heart rate, and cognitive function of spontaneously hypertensive rats." Physiological reports vol. 9,7 (2021): e14812. doi: https://doi.org/10.14814/phy2.14812
Stoyell-Conti FF, Chabbra A, Puthentharayil J, Rigatto K, Speth RC. Chronic administration of pharmacological doses of angiotensin 1-7 and iodoangiotensin 1-7 has minimal effects on blood pressure, heart rate, and cognitive function of spontaneously hypertensive rats. Physiol Rep. 2021 Apr;9(7):e14812. doi: 10.14814/phy2.14812. PMID: 33904655; PMCID: PMC8077095.
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Physiol Rep. 2021 Apr;9(7):e14812. doi: 10.14814/phy2.14812.

Chronic administration of pharmacological doses of angiotensin 1-7 and iodoangiotensin 1-7 has minimal effects on blood pressure, heart rate, and cognitive function of spontaneously hypertensive rats.

Physiological reports

Filipe F Stoyell-Conti, Alesa Chabbra, Joseph Puthentharayil, Katya Rigatto, Robert C Speth

Affiliations

  1. College of Pharmacy, Nova Southeastern University, Fort Lauderdale, FL, USA.
  2. Surgery Department, University of Miami, Miami, FL, USA.
  3. Halmos College of Natural Science & Oceanography, Nova Southeastern University, Fort Lauderdale, FL, USA.
  4. Institute for Neuro-Immune Medicine, Nova Southeastern University, Fort Lauderdale, FL, USA.
  5. Laboratório de Fisiologia Translacional, Universidade Federal de Ciências da Saúde de Porto Alegre, Porto Alegre, RS, Brazil.
  6. Department of Pharmacology and Physiology, College of Medicine, Georgetown University, Washington, DC, USA.

PMID: 33904655 PMCID: PMC8077095 DOI: 10.14814/phy2.14812

Abstract

Cardiovascular diseases are the principal cause of death worldwide, with hypertension being the most common cardiovascular disease risk factor. High blood pressure (BP) is also associated with an increased risk of poor cognitive performance and dementia including Alzheimer's disease. Angiotensin 1-7 (Ang 1-7), a product of the renin-angiotensin system (RAS), exhibits central and peripheral actions to reduce BP. Recent data from our lab reveals that the addition of a non-radioactive iodine molecule to the tyrosine in position 4 of Ang 1-7 (iodoAng 1-7) makes it ~1000-fold more potent than Ang 1-7 in competing for the

© 2021 The Authors. Physiological Reports published by Wiley Periodicals LLC on behalf of The Physiological Society and the American Physiological Society.

Keywords: angiotensin 1-7; angiotensin IV; blood pressure; cognition; heart rate; iodoAngiotensin 1-7; memory; spontaneously hypertensive rat (SHR)

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