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Acta Anaesthesiol Scand. 1988 Nov;32(8):638-42. doi: 10.1111/j.1399-6576.1988.tb02801.x.

Hepatic drug disposition in multiple organ failure.

Acta anaesthesiologica Scandinavica

W Schregel, H D Kuntz, M Vitt

Affiliations

  1. Department of Anesthesiology and Intensive Care Medicine, Knappschaftskrankenhaus, Ruhr-Uni-Bochum, W. Germany.

PMID: 3213389 DOI: 10.1111/j.1399-6576.1988.tb02801.x

Abstract

In 15 patients with multiple organ failure of septic etiology, some principal partial hepatic functions of drug disposition were measured by the test substances galactose, indocyanine green, theophylline and 4-methylumbelliferon. Glucuronidation was not impaired in any case, whereas flow-limited and capacity-limited drug elimination can be influenced. Drug monitoring and intense clinical observation seem necessary to improve drug therapy and the outcome of patients with multiple organ failure.

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