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Quant Imaging Med Surg. 2021 May;11(5):2169-2186. doi: 10.21037/qims-20-845.

Photoacoustic imaging as a highly efficient and precise imaging strategy for the evaluation of brain diseases.

Quantitative imaging in medicine and surgery

Ting Qiu, Yintao Lan, Weijian Gao, Mengyu Zhou, Shiqi Liu, Wenyan Huang, Sujuan Zeng, Janak L Pathak, Bin Yang, Jian Zhang

Affiliations

  1. Department of Biomedical Engineering, School of Basic Medical Sciences, Guangzhou Medical University, Guangzhou, China.
  2. Affiliated Stomatology Hospital of Guangzhou Medical University, Guangzhou Key Laboratory of Basic and Applied Research of Oral Regenerative Medicine, Guangzhou, China.

PMID: 33936997 PMCID: PMC8047382 DOI: 10.21037/qims-20-845

Abstract

Photoacoustic imaging (PAI) is an emerging imaging strategy with a unique combination of rich optical contrasts, high ultrasound spatial resolution, and deep penetration depth without ionizing radiation. Taking advantage of the features mentioned above, PAI has been widely applied to preclinical studies in diverse fields, such as vascular biology, cardiology, neurology, ophthalmology, dermatology, gastroenterology, and oncology. Among various biomedical applications, photoacoustic brain imaging has great importance due to the brain's complex anatomy and the variability of brain disease. In this review, we aimed to introduce a novel and effective imaging modality for diagnosing brain diseases. Firstly, a brief overview of two major types of PAI system was provided. Then, PAI's major preclinical applications in brain diseases were introduced, including early diagnosis of brain tumors, subtle changes in the chemotherapy response, epileptic activity and brain injury, foreign body, and brain plaque. Finally, a perspective of the remaining challenges of PAI was given for future advancements.

2021 Quantitative Imaging in Medicine and Surgery. All rights reserved.

Keywords: Photoacoustic imaging; brain diseases; diagnosis; imaging modality

Conflict of interest statement

Conflicts of Interest: All authors have completed the ICMJE uniform disclosure form (available at http://dx.doi.org/10.21037/qims-20-845). The authors have no conflicts of interest to declare.

References

  1. Science. 2000 Feb 4;287(5454):783, 785 - PubMed
  2. Science. 2012 Mar 23;335(6075):1458-62 - PubMed
  3. Sensors (Basel). 2020 Jul 21;20(14): - PubMed
  4. Photoacoustics. 2013 Sep 24;1(3-4):49-53 - PubMed
  5. Biophys J. 2013 Aug 20;105(4):841-7 - PubMed
  6. Neurophotonics. 2016 Jan;3(1):010901 - PubMed
  7. J Biomed Opt. 2011 Jan-Feb;16(1):016015 - PubMed
  8. Neuroimage. 2013 Feb 1;66:240-8 - PubMed
  9. Lancet Neurol. 2007 Feb;6(2):182-7 - PubMed
  10. Electromagn Waves (Camb). 2014;147:1-22 - PubMed
  11. Brain Res. 2015 Oct 14;1623:174-92 - PubMed
  12. PLoS One. 2014 Apr 28;9(4):e96118 - PubMed
  13. Nat Nanotechnol. 2014 Aug;9(8):631-8 - PubMed
  14. ACS Nano. 2017 Mar 28;11(3):3298-3310 - PubMed
  15. J Biomed Opt. 2015 Jun;20(6):066010 - PubMed
  16. Nat Protoc. 2011 Jul 07;6(8):1121-9 - PubMed
  17. Nat Biotechnol. 2006 Jul;24(7):848-51 - PubMed
  18. Quant Imaging Med Surg. 2019 May;9(5):807-814 - PubMed
  19. Nanoscale. 2018 Feb 22;10(8):3631-3638 - PubMed
  20. Opt Lett. 2011 Apr 1;36(7):1134-6 - PubMed
  21. Cell. 2011 Mar 4;144(5):646-74 - PubMed
  22. J Nucl Med. 2015 Dec;56(12):1942-7 - PubMed
  23. Nanoscale. 2014 Apr 21;6(8):4078-82 - PubMed
  24. Adv Sci (Weinh). 2017 Dec 05;5(2):1700277 - PubMed
  25. Am J Pathol. 1998 Sep;153(3):725-33 - PubMed
  26. J Autism Dev Disord. 2000 Jun;30(3):205-23 - PubMed
  27. Pediatr Emerg Care. 2001 Oct;17(5):354-5 - PubMed
  28. J Trauma Acute Care Surg. 2019 Mar;86(3):415-423 - PubMed
  29. J Nucl Med. 2002 Oct;43(10):1304-9 - PubMed
  30. Med Phys. 2013 Jan;40(1):013302 - PubMed
  31. Radiology. 2018 Nov;289(2):517-534 - PubMed
  32. Neurocrit Care. 2017 Sep;27(Suppl 1):82-88 - PubMed
  33. Phys Med Biol. 2008 Apr 7;53(7):1921-31 - PubMed
  34. Neuroimage. 2013 Jan 1;64:257-66 - PubMed
  35. J Biomed Opt. 2012 Jun;17(6):061211 - PubMed
  36. J Biomed Opt. 2012 Jun;17(6):061222 - PubMed
  37. Photoacoustics. 2019 Dec 26;17:100153 - PubMed
  38. Quant Imaging Med Surg. 2019 May;9(5):799-806 - PubMed
  39. J Biomed Opt. 2015 May;20(5):50504 - PubMed
  40. Lancet. 2008 May 10;371(9624):1612-23 - PubMed
  41. Nat Methods. 2015 May;12(5):407-10 - PubMed
  42. Theranostics. 2020 Jan 1;10(2):816-828 - PubMed
  43. Nat Med. 2012 Apr 15;18(5):829-34 - PubMed
  44. IEEE Trans Biomed Eng. 2014 May;61(5):1380-9 - PubMed
  45. Radiol Med. 2013 Mar;118(2):303-10 - PubMed
  46. J Biomed Opt. 2012 Nov;17(11):110506 - PubMed
  47. Med Phys. 2010 Nov;37(11):6096-100 - PubMed
  48. Scand J Psychol. 2000 Jun;41(2):113-21 - PubMed
  49. Neurology. 1994 May;44(5):850-6 - PubMed
  50. Radiology. 2019 Sep;292(3):564-572 - PubMed
  51. Opt Lett. 2014 Apr 1;39(7):2214-7 - PubMed
  52. J Neural Eng. 2014 Aug;11(4):046013 - PubMed
  53. J Biomed Opt. 2012 Jul;17(7):076012 - PubMed
  54. Lancet Neurol. 2016 Aug;15(9):913-924 - PubMed
  55. Asian J Neurosurg. 2016 Apr-Jun;11(2):143-5 - PubMed
  56. PLoS One. 2012;7(1):e30491 - PubMed
  57. J Nucl Med. 1998 Feb;39(2):285-93 - PubMed
  58. Cardiovasc Diagn Ther. 2016 Dec;6(6):493-507 - PubMed
  59. Philos Trans R Soc Lond B Biol Sci. 1997 Jun 29;352(1354):727-35 - PubMed
  60. Biomed Opt Express. 2012 Jun 1;3(6):1427-32 - PubMed
  61. Neurology. 2006 Jan 10;66(1):23-9 - PubMed
  62. J Head Trauma Rehabil. 2001 Aug;16(4):343-55 - PubMed
  63. Trends Biotechnol. 2016 May;34(5):420-433 - PubMed
  64. Neuron. 2017 Dec 6;96(5):966-988 - PubMed
  65. Eur J Nucl Med Mol Imaging. 2010 Jun;37(6):1069-76 - PubMed
  66. Trends Biotechnol. 2019 Dec;37(12):1315-1326 - PubMed
  67. Radiology. 2020 May;295(2):469-474 - PubMed
  68. ACS Nano. 2014 Dec 23;8(12):12141-50 - PubMed
  69. Epilepsia. 2006 Jul;47(7):1094-120 - PubMed
  70. Opt Lett. 2008 May 1;33(9):929-31 - PubMed
  71. J Neurosurg. 2001 Sep;95(3):503-6 - PubMed
  72. Acta Neurochir (Wien). 2004 Aug;146(8):847-50 - PubMed
  73. Epilepsia. 2005 Apr;46(4):470-2 - PubMed
  74. J Neurosci Methods. 2013 Jun 15;216(2):142-5 - PubMed
  75. Cell Rep. 2019 Mar 5;26(10):2833-2846.e3 - PubMed
  76. Nat Commun. 2010 Jul 27;1:41 - PubMed
  77. ACS Nano. 2014 Feb 25;8(2):1231-42 - PubMed
  78. Nanotechnology. 2015 Aug 7;26(31):315701 - PubMed
  79. AJR Am J Roentgenol. 1994 Jan;162(1):189-94 - PubMed
  80. Neurosci Res. 2015 Feb;91:57-62 - PubMed
  81. West J Emerg Med. 2011 Nov;12(4):467-71 - PubMed
  82. Neuroimage. 2013 Jan 15;65:522-8 - PubMed
  83. Int J Mol Sci. 2014 Dec 18;15(12):23616-39 - PubMed
  84. Chem Sci. 2017 Apr 1;8(4):2710-2716 - PubMed
  85. Small. 2014 Apr 24;10(8):1585-93, 1441 - PubMed
  86. J Neurotrauma. 2014 Dec 15;31(24):1998-2002 - PubMed
  87. J Biomed Opt. 2011 Jul;16(7):076003 - PubMed
  88. Neurobiol Aging. 2007 Sep;28(9):1297-306 - PubMed
  89. Quant Imaging Med Surg. 2019 Feb;9(2):160-170 - PubMed
  90. J Biomed Opt. 2010 May-Jun;15(3):036019 - PubMed
  91. Photoacoustics. 2015 Jan 13;3(2):55-9 - PubMed
  92. Sensors (Basel). 2017 Feb 12;17(2): - PubMed
  93. PLoS One. 2013 Dec 26;8(12):e83045 - PubMed
  94. Nat Mater. 2011 Apr;10(4):324-32 - PubMed
  95. Cancer Biol Med. 2016 Sep;13(3):349-359 - PubMed
  96. J Biomed Opt. 2012 Jun;17(6):066016 - PubMed
  97. Radiology. 1992 Jul;184(1):243-8 - PubMed
  98. Photoacoustics. 2018 May 31;10:65-73 - PubMed
  99. Nat Commun. 2012 Jan 10;3:618 - PubMed
  100. Nanoscale. 2015 Apr 14;7(14):6304-10 - PubMed
  101. Annu Rev Biomed Eng. 2014 Jul 11;16:155-85 - PubMed
  102. Curr Opin Chem Biol. 2018 Aug;45:104-112 - PubMed
  103. Quant Imaging Med Surg. 2020 Nov;10(11):2081-2084 - PubMed
  104. Neurosurgery. 2010 Apr;66(4):736-43 - PubMed
  105. Neuroimage. 2017 Nov 1;161:232-240 - PubMed

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