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Zhang H, Jin Y, Chi C, et al. Sponge particulates for biomedical applications: Biofunctionalization, multi-drug shielding, and theranostic applications. Biomaterials. 2021;273:120824doi: 10.1016/j.biomaterials.2021.120824.
Zhang, H., Jin, Y., Chi, C., Han, G., Jiang, W., Wang, Z., Cheng, H., Zhang, C., Wang, G., Sun, C., Chen, Y., Xi, Y., Liu, M., Gao, X., Lin, X., Lv, L., Zhou, J., & Ding, Y. (2021). Sponge particulates for biomedical applications: Biofunctionalization, multi-drug shielding, and theranostic applications. Biomaterials, 273120824. https://doi.org/10.1016/j.biomaterials.2021.120824
Zhang, Huaqing, et al. "Sponge particulates for biomedical applications: Biofunctionalization, multi-drug shielding, and theranostic applications." Biomaterials vol. 273 (2021): 120824. doi: https://doi.org/10.1016/j.biomaterials.2021.120824
Zhang H, Jin Y, Chi C, Han G, Jiang W, Wang Z, Cheng H, Zhang C, Wang G, Sun C, Chen Y, Xi Y, Liu M, Gao X, Lin X, Lv L, Zhou J, Ding Y. Sponge particulates for biomedical applications: Biofunctionalization, multi-drug shielding, and theranostic applications. Biomaterials. 2021 Jun;273:120824. doi: 10.1016/j.biomaterials.2021.120824. Epub 2021 Apr 15. PMID: 33894401.
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Biomaterials. 2021 Jun;273:120824. doi: 10.1016/j.biomaterials.2021.120824. Epub 2021 Apr 15.

Sponge particulates for biomedical applications: Biofunctionalization, multi-drug shielding, and theranostic applications.

Biomaterials

Huaqing Zhang, Yi Jin, Cheng Chi, Guochen Han, Wenxin Jiang, Zhen Wang, Hao Cheng, Chenshuang Zhang, Gang Wang, Chenhua Sun, Yun Chen, Yilong Xi, Mengting Liu, Xie Gao, Xiujun Lin, Lingyu Lv, Jianping Zhou, Yang Ding

Affiliations

  1. Key Laboratory of Drug Quality Control and Pharmacovigilance, China Pharmaceutical University, Ministry of Education, Nanjing 210009, China; State Key Laboratory of Natural Medicines, Department of Pharmaceutics, China Pharmaceutical University, Nanjing 210009, China.
  2. Key Laboratory of Drug Quality Control and Pharmacovigilance, China Pharmaceutical University, Ministry of Education, Nanjing 210009, China.
  3. Key Laboratory of Drug Quality Control and Pharmacovigilance, China Pharmaceutical University, Ministry of Education, Nanjing 210009, China; State Key Laboratory of Natural Medicines, Department of Pharmaceutics, China Pharmaceutical University, Nanjing 210009, China; NMPA Key Laboratory for Research and Evaluation of Pharmaceutical Preparations and Excipients, Nanjing 210009, China. Electronic address: [email protected].
  4. State Key Laboratory of Natural Medicines, Department of Pharmaceutics, China Pharmaceutical University, Nanjing 210009, China; NMPA Key Laboratory for Research and Evaluation of Pharmaceutical Preparations and Excipients, Nanjing 210009, China. Electronic address: [email protected].

PMID: 33894401 DOI: 10.1016/j.biomaterials.2021.120824

Abstract

Sponge particulates have attracted enormous attention in biomedical applications for superior properties, including large porosity, elastic deformation, capillary action, and three-dimensional (3D) reaction environment. Especially, the tiny porous structures make sponge particulates a promising platform for drug delivery, tissue engineering, anti-infection, and wound healing by providing abundant reservoirs of broad surface and internal network for cargo shielding and shuttling. To control the sponge-like morphology and improve the diversity of drug loading, some optimized preparation techniques of sponge particulates have been developed, contributing to the simplified preparation process and improved production reproducibility. Bio-functionalized strategies, including target modification, cell membrane camouflage, and hydrogel of sponge particulates have been applied to modulate the properties, improve the performance, and extend the applications. In this review, we highlight the unique physical properties and functions, current manufacturing techniques, and an overview of spongy particulates in biomedical applications, especially in inhibition of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infectivity. Moreover, the current challenges and prospects of sponge particulates are discussed rationally, providing an insight into developing vibrant fields of sponge particulates-based biomedicine.

Copyright © 2021 Elsevier Ltd. All rights reserved.

Keywords: Biofunctionalization; Biomedical applications; Large porosity; SARS-CoV-2; Sponge particulates

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