Cochrane Database Syst Rev. 2021 Apr 15;4:CD013346. doi: 10.1002/14651858.CD013346.pub2.
Abdominal ultrasound and alpha-foetoprotein for the diagnosis of hepatocellular carcinoma in adults with chronic liver disease.
The Cochrane database of systematic reviews
Agostino Colli, Tin Nadarevic, Damir Miletic, Vanja Giljaca, Mirella Fraquelli, Davor Štimac, Giovanni Casazza
Affiliations
Affiliations
- Department of Transfusion Medicine and Haematology, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milano, Italy.
- Department of Radiology, Clinical Hospital Centre Rijeka, Rijeka, Croatia.
- Department of Radiology , Clinical Hospital Centre Rijeka, Rijeka, Croatia.
- Department of Gastroenterology, Heart of England NHS Foundation Trust, Birmingham, UK.
- Gastroenterology and Endoscopy Unit, Fondazione IRCCS Ca´ Granda - Ospedale Maggiore Policlinico, Department of Pathophysiology and Transplantation, Università degli Studi di Milano, Milan, Italy.
- Department of Gastroenterology, Clinical Hospital Centre Rijeka, Rijeka, Croatia.
- Dipartimento di Scienze Biomediche e Cliniche "L. Sacco", Università degli Studi di Milano, Milan, Italy.
PMID: 33855699
PMCID: PMC8078581 DOI: 10.1002/14651858.CD013346.pub2
Abstract
BACKGROUND: Hepatocellular carcinoma (HCC) occurs mostly in people with chronic liver disease and ranks sixth in terms of global instances of cancer, and fourth in terms of cancer deaths for men. Despite that abdominal ultrasound (US) is used as an initial test to exclude the presence of focal liver lesions and serum alpha-foetoprotein (AFP) measurement may raise suspicion of HCC occurrence, further testing to confirm diagnosis as well as staging of HCC is required. Current guidelines recommend surveillance programme using US, with or without AFP, to detect HCC in high-risk populations despite the lack of clear benefits on overall survival. Assessing the diagnostic accuracy of US and AFP may clarify whether the absence of benefit in surveillance programmes could be related to under-diagnosis. Therefore, assessment of the accuracy of these two tests for diagnosing HCC in people with chronic liver disease, not included in surveillance programmes, is needed.
OBJECTIVES: Primary: the diagnostic accuracy of US and AFP, alone or in combination, for the diagnosis of HCC of any size and at any stage in adults with chronic liver disease, either in a surveillance programme or in a clinical setting. Secondary: to assess the diagnostic accuracy of abdominal US and AFP, alone or in combination, for the diagnosis of resectable HCC; to compare the diagnostic accuracy of the individual tests versus the combination of both tests; to investigate sources of heterogeneity in the results.
SEARCH METHODS: We searched the Cochrane Hepato-Biliary Group Controlled Trials Register, the Cochrane Hepato-Biliary Group Diagnostic-Test-Accuracy Studies Register, Cochrane Library, MEDLINE, Embase, LILACS, Science Citation Index Expanded, until 5 June 2020. We applied no language or document-type restrictions.
SELECTION CRITERIA: Studies assessing the diagnostic accuracy of US and AFP, independently or in combination, for the diagnosis of HCC in adults with chronic liver disease, with cross-sectional and case-control designs, using one of the acceptable reference standards, such as pathology of the explanted liver, histology of resected or biopsied focal liver lesion, or typical characteristics on computed tomography, or magnetic resonance imaging, all with a six-months follow-up.
DATA COLLECTION AND ANALYSIS: We independently screened studies, extracted data, and assessed the risk of bias and applicability concerns, using the QUADAS-2 checklist. We presented the results of sensitivity and specificity, using paired forest-plots, and tabulated the results. We used a hierarchical meta-analysis model where appropriate. We presented uncertainty of the accuracy estimates using 95% confidence intervals (CIs). We double-checked all data extractions and analyses.
MAIN RESULTS: We included 373 studies. The index-test was AFP (326 studies, 144,570 participants); US (39 studies, 18,792 participants); and a combination of AFP and US (eight studies, 5454 participants). We judged at high-risk of bias all but one study. Most studies used different reference standards, often inappropriate to exclude the presence of the target condition, and the time-interval between the index test and the reference standard was rarely defined. Most studies with AFP had a case-control design. We also had major concerns for the applicability due to the characteristics of the participants. As the primary studies with AFP used different cut-offs, we performed a meta-analysis using the hierarchical-summary-receiver-operating-characteristic model, then we carried out two meta-analyses including only studies reporting the most used cut-offs: around 20 ng/mL or 200 ng/mL. AFP cut-off 20 ng/mL: for HCC (147 studies) sensitivity 60% (95% CI 58% to 62%), specificity 84% (95% CI 82% to 86%); for resectable HCC (six studies) sensitivity 65% (95% CI 62% to 68%), specificity 80% (95% CI 59% to 91%). AFP cut-off 200 ng/mL: for HCC (56 studies) sensitivity 36% (95% CI 31% to 41%), specificity 99% (95% CI 98% to 99%); for resectable HCC (two studies) one with sensitivity 4% (95% CI 0% to 19%), specificity 100% (95% CI 96% to 100%), and one with sensitivity 8% (95% CI 3% to 18%), specificity 100% (95% CI 97% to 100%). US: for HCC (39 studies) sensitivity 72% (95% CI 63% to 79%), specificity 94% (95% CI 91% to 96%); for resectable HCC (seven studies) sensitivity 53% (95% CI 38% to 67%), specificity 96% (95% CI 94% to 97%). Combination of AFP (cut-off of 20 ng/mL) and US: for HCC (six studies) sensitivity 96% (95% CI 88% to 98%), specificity 85% (95% CI 73% to 93%); for resectable HCC (two studies) one with sensitivity 89% (95% CI 73% to 97%), specificity of 83% (95% CI 76% to 88%), and one with sensitivity 79% (95% CI 54% to 94%), specificity 87% (95% CI 79% to 94%). The observed heterogeneity in the results remains mostly unexplained, and only in part referable to different cut-offs or settings (surveillance programme compared to clinical series). The sensitivity analyses, excluding studies published as abstracts, or with case-control design, showed no variation in the results. We compared the accuracy obtained from studies with AFP (cut-off around 20 ng/mL) and US: a direct comparison in 11 studies (6674 participants) showed a higher sensitivity of US (81%, 95% CI 66% to 90%) versus AFP (64%, 95% CI 56% to 71%) with similar specificity: US 92% (95% CI 83% to 97%) versus AFP 89% (95% CI 79% to 94%). A direct comparison of six studies (5044 participants) showed a higher sensitivity (96%, 95% CI 88% to 98%) of the combination of AFP and US versus US (76%, 95% CI 56% to 89%) with similar specificity: AFP and US 85% (95% CI 73% to 92%) versus US 93% (95% CI 80% to 98%).
AUTHORS' CONCLUSIONS: In the clinical pathway for the diagnosis of HCC in adults, AFP and US, singularly or in combination, have the role of triage-tests. We found that using AFP, with 20 ng/mL as a cut-off, about 40% of HCC occurrences would be missed, and with US alone, more than a quarter. The combination of the two tests showed the highest sensitivity and less than 5% of HCC occurrences would be missed with about 15% of false-positive results. The uncertainty resulting from the poor study quality and the heterogeneity of included studies limit our ability to confidently draw conclusions based on our results.
Copyright © 2021 The Cochrane Collaboration. Published by John Wiley & Sons, Ltd.
References
- Proteomics Clin Appl. 2018 Nov;12(6):e1800062 - PubMed
- J Hepatol. 1994 Jan;20(1):65-71 - PubMed
- Arab J Gastroenterol. 2014 Sep-Dec;15(3-4):142-7 - PubMed
- Clin Gastroenterol Hepatol. 2006 Mar;4(3):361-8 - PubMed
- PLoS One. 2018 Mar 14;13(3):e0192748 - PubMed
- Clin Res Hepatol Gastroenterol. 2020 Feb;44(1):21-28 - PubMed
- Eur J Gastroenterol Hepatol. 2016 May;28(5):599-605 - PubMed
- Clin Chim Acta. 2011 Jan 14;412(1-2):152-8 - PubMed
- Hepatology. 2000 Aug;32(2):200-4 - PubMed
- Presse Med. 1988 Sep 24;17(32):1629-32 - PubMed
- Ital J Gastroenterol. 1990 Aug;22(4):190-4 - PubMed
- Scand J Gastroenterol. 2016 Mar;51(3):344-53 - PubMed
- PLoS One. 2016 Jun 16;11(6):e0156801 - PubMed
- J Gastroenterol Hepatol. 2001 Dec;16(12):1378-83 - PubMed
- Yonsei Med J. 2015 Sep;56(5):1296-306 - PubMed
- Hepatology. 2013 Apr;57(4):1416-25 - PubMed
- JAMA Oncol. 2017 Dec 1;3(12):1683-1691 - PubMed
- Cancer Epidemiol Biomarkers Prev. 2019 Mar;28(3):531-538 - PubMed
- J Assoc Physicians India. 1981 Feb;29(2):129-32 - PubMed
- J Clin Epidemiol. 2011 Apr;64(4):401-6 - PubMed
- Int J Circumpolar Health. 2016 May 18;75:31115 - PubMed
- F1000Res. 2018 Aug 24;7:1339 - PubMed
- PLoS One. 2020 May 6;15(5):e0232247 - PubMed
- Transplant Proc. 2003 Feb;35(1):348-9 - PubMed
- Br J Radiol. 1987 Dec;60(720):1221-2 - PubMed
- Cancer Manag Res. 2019 Dec 17;11:10555-10562 - PubMed
- Nihon Naika Gakkai Zasshi. 1991 Oct 10;80(10):1637-44 - PubMed
- J Gastrointest Cancer. 2019 Sep;50(3):434-441 - PubMed
- Cancer Biomark. 2018 Feb 14;21(3):603-612 - PubMed
- Clin Exp Gastroenterol. 2019 Feb 01;12:51-66 - PubMed
- J Ultrasound Med. 1996 Jul;15(7):497-502; quiz 503-4 - PubMed
- Hepatology. 2019 Aug;70(2):547-562 - PubMed
- Hepatogastroenterology. 2009 May-Jun;56(91-92):763-7 - PubMed
- Future Oncol. 2012 Dec;8(12):1525-8 - PubMed
- Clin Gastroenterol Hepatol. 2016 Mar;14(3):469-475.e2 - PubMed
- Asian Pac J Cancer Prev. ;18(1):121-127 - PubMed
- J Clin Exp Hepatol. 2016 Sep;6(3):186-194 - PubMed
- Asian Pac J Cancer Prev. ;18(4):1105-1111 - PubMed
- Open Access Maced J Med Sci. 2018 Sep 24;6(9):1668-1673 - PubMed
- Clin Chim Acta. 2011 Nov 20;412(23-24):2310-5 - PubMed
- Cancer Epidemiol Biomarkers Prev. 2012 May;21(5):793-9 - PubMed
- J Clin Gastroenterol. 2005 Feb;39(2):152-9 - PubMed
- J Egypt Natl Canc Inst. 2016 Dec;28(4):257-262 - PubMed
- Gastroenterology. 2009 Jan;136(1):138-48 - PubMed
- PLoS One. 2014 Sep 19;9(9):e107986 - PubMed
- Br Med J. 1978 Sep 2;2(6138):661-3 - PubMed
- Cancer Biomark. 2018;23(2):235-242 - PubMed
- Hepatology. 2014 Mar;59(3):986-95 - PubMed
- J Cell Biochem. 2018 Nov 13;: - PubMed
- PLoS Med. 2014 Apr 01;11(4):e1001624 - PubMed
- Diagn Interv Radiol. 2014 May-Jun;20(3):209-21 - PubMed
- Ann Hepatol. 2013 Sep-Oct;12(5):774-81 - PubMed
- Sci Pharm. 2013 Aug 08;81(3):763-75 - PubMed
- Gastroenterology. 2010 Feb;138(2):493-502 - PubMed
- Hepatology. 2018 Feb;67(2):662-675 - PubMed
- Hepatol Res. 2014 Dec;44(13):1347-56 - PubMed
- Korean J Gastroenterol. 2017 Apr 25;69(4):232-238 - PubMed
- Lancet. 2012 Mar 31;379(9822):1245-55 - PubMed
- BMC Gastroenterol. 2010 May 18;10:46 - PubMed
- J Clin Epidemiol. 2020 Jun;122:142-152 - PubMed
- Am J Gastroenterol. 2000 Apr;95(4):1036-40 - PubMed
- Anticancer Res. 2013 Mar;33(3):1013-21 - PubMed
- Gut. 2019 Dec;68(12):2195-2205 - PubMed
- Korean J Hepatol. 2006 Sep;12(3):404-11 - PubMed
- Ann Surg Oncol. 2018 Jun;25(6):1686-1694 - PubMed
- J Cancer. 2019 Oct 8;10(23):5862-5873 - PubMed
- J Proteome Res. 2010 Feb 5;9(2):1096-103 - PubMed
- Hepatology. 2012 Oct;56(4):1371-9 - PubMed
- Clin Liver Dis. 2015 Feb;19(1):99-121 - PubMed
- Mol Cell Proteomics. 2012 Feb;11(2):M111.010694 - PubMed
- Oncology. 2001;61(4):275-83 - PubMed
- Sov Med. 1974 Jun;37(6):128-30 - PubMed
- Hepatology. 2003 May;37(5):1114-21 - PubMed
- Cancer. 1988 Jul 15;62(2):227-32 - PubMed
- Am J Med. 2017 Sep;130(9):1099-1106.e1 - PubMed
- Int J Cancer. 2015 Jul 15;137(2):385-394 - PubMed
- Biochemistry. 1991 May 21;30(20):5061-6 - PubMed
- Gastroenterology. 2003 Jul;125(1):89-97 - PubMed
- J Clin Gastroenterol. 2012 Jan;46(1):71-7 - PubMed
- Clin Gastroenterol Hepatol. 2019 Aug;17(9):1886-1893.e5 - PubMed
- Int J Cancer. 2011 Nov 15;129(10):2463-72 - PubMed
- Scand J Clin Lab Invest. 2017 May;77(3):175-183 - PubMed
- Dig Dis Sci. 2010 Dec;55(12):3568-75 - PubMed
- Liver Int. 2011 Nov;31(10):1468-76 - PubMed
- AJR Am J Roentgenol. 1998 Aug;171(2):433-5 - PubMed
- Lancet Oncol. 2015 Jul;16(7):804-15 - PubMed
- J Cancer Res Ther. 2014 Dec;10 Suppl:304-6 - PubMed
- Arch Med Sci. 2019 Oct;15(6):1454-1461 - PubMed
- Ann Intern Med. 2014 Aug 19;161(4):261-9 - PubMed
- J Hepatol. 2020 Apr;72(4):718-724 - PubMed
- Anticancer Res. 2012 Jan;32(1):141-5 - PubMed
- Int J Hepatol. 2015;2015:146389 - PubMed
- World J Gastroenterol. 2013 Dec 21;19(47):8808-21 - PubMed
- Biomed Res Int. 2017;2017:5358615 - PubMed
- Int J Cancer. 2013 Jul 15;133(2):408-15 - PubMed
- Ann Hepatol. 2020 Mar - Apr;19(2):179-185 - PubMed
- Asian Pac J Cancer Prev. 2016;17(8):4077-82 - PubMed
- Med Oncol. 2010 Jun;27(2):339-45 - PubMed
- Br J Cancer. 2015 Sep 1;113(5):756-62 - PubMed
- Cancer. 1985 Aug 1;56(3):660-6 - PubMed
- Eur J Gastroenterol Hepatol. 2016 Apr;28(4):412-20 - PubMed
- Asian Pac J Cancer Prev. 2013;14(12):7345-9 - PubMed
- HPB (Oxford). 2014 Apr;16(4):366-72 - PubMed
- Br J Surg. 1999 Aug;86(8):1032-8 - PubMed
- Rev Esp Enferm Dig. 2012 Jun;104(6):298-304 - PubMed
- Hepatogastroenterology. 2015 Jun;62(140):978-81 - PubMed
- Clin Chem Lab Med. 2018 Feb 23;56(3):479-484 - PubMed
- Cancer Epidemiol Biomarkers Prev. 2017 Jul;26(7):1085-1092 - PubMed
- Chin Med J (Engl). 1990 Mar;103(3):228-32 - PubMed
- Onco Targets Ther. 2020 Jan 28;13:827-840 - PubMed
- Hepatology. 2011 Dec;54(6):1998-2004 - PubMed
- J Coll Physicians Surg Pak. 2019 Oct;29(10):972-976 - PubMed
- Onco Targets Ther. 2020 Mar 09;13:2021-2030 - PubMed
- Cancer Causes Control. 2012 Mar;23(3):455-62 - PubMed
- Gut. 2001 Feb;48(2):251-9 - PubMed
- Zhonghua Zhong Liu Za Zhi. 2013 Jul;35(7):505-8 - PubMed
- J Gastroenterol Hepatol. 2011 Apr;26(4):751-8 - PubMed
- J Med Virol. 2020 Feb 11;: - PubMed
- Hepatology. 2019 Jun;69(6):2489-2501 - PubMed
- Cancer. 2016 May 1;122(9):1312-37 - PubMed
- Clin Gastroenterol Hepatol. 2009 Jan;7(1):104-13 - PubMed
- Hepatogastroenterology. 1990 Apr;37(2):188-93 - PubMed
- World J Gastroenterol. 2010 Sep 21;16(35):4410-5 - PubMed
- PLoS One. 2017 Mar 15;12(3):e0173897 - PubMed
- World J Gastroenterol. 2005 Jul 14;11(26):4120-3 - PubMed
- Lancet Infect Dis. 2015 Apr;15(4):397-404 - PubMed
- Liver Int. 2019 Oct;39(10):1964-1974 - PubMed
- Mol Med Rep. 2018 Mar;17(3):4720-4728 - PubMed
- Lancet. 2018 Mar 31;391(10127):1301-1314 - PubMed
- PLoS One. 2020 Apr 24;15(4):e0232211 - PubMed
- Aliment Pharmacol Ther. 2007 Nov 1;26(9):1187-94 - PubMed
- Cancer Res. 1972 Sep;32(9):1941-6 - PubMed
- J Gastroenterol Hepatol. 2001 May;16(5):553-9 - PubMed
- Blood. 2003 Jul 1;102(1):78-82 - PubMed
- Transplant Proc. 1998 May;30(3):780-1 - PubMed
- Liver Transpl. 2004 May;10(5):631-7 - PubMed
- Int J Biol Markers. 1990 Jul-Sep;5(3):121-6 - PubMed
- Diagn Pathol. 2015 Aug 04;10:133 - PubMed
- Mol Diagn Ther. 2015 Aug;19(4):213-20 - PubMed
- Hepatol Res. 2018 Oct;48(11):872-881 - PubMed
- Iran J Public Health. 2019 Feb;48(2):314-322 - PubMed
- Clin Gastroenterol Hepatol. 2014 Dec;12(12):2138-9 - PubMed
- Hepatol Int. 2008 Mar;2(1):17-30 - PubMed
- Rofo. 1991 Apr;154(4):398-406 - PubMed
- Sci China Life Sci. 2013 Jul;56(7):638-46 - PubMed
- Gastroenterology. 1984 Mar;86(3):495-502 - PubMed
- Biomed Res Int. 2020 Apr 20;2020:5819385 - PubMed
- Int J Gen Med. 2020 Apr 30;13:147-155 - PubMed
- Dig Liver Dis. 2005 Mar;37(3):200-5 - PubMed
- Ann Intern Med. 2011 Oct 18;155(8):529-36 - PubMed
- Cancer Biomark. 2017;18(3):241-248 - PubMed
- Eur Rev Med Pharmacol Sci. 2019 Apr;23(8):3302-3310 - PubMed
- J Gastroenterol Hepatol. 1989 Jan-Feb;4(1):17-24 - PubMed
- Biomed Pharmacother. 2018 Jun;102:653-669 - PubMed
- Clin Lab. 2012;58(9-10):1023-8 - PubMed
- Semin Liver Dis. 1999;19(3):329-38 - PubMed
- PLoS One. 2014 Oct 13;9(10):e110366 - PubMed
- Asian Pac J Cancer Prev. 2018 Mar 27;19(3):811-817 - PubMed
- Aliment Pharmacol Ther. 2009 Jul;30(1):37-47 - PubMed
- Clin Chim Acta. 2009 Jan;399(1-2):97-101 - PubMed
- J Med Virol. 2010 Jul;82(7):1115-25 - PubMed
- PLoS One. 2018 Aug 31;13(8):e0203149 - PubMed
- Sci Rep. 2017 Jan 12;7:38918 - PubMed
- Hepatogastroenterology. 1987 Jun;34(3):100-2 - PubMed
- J Med Imaging Radiat Oncol. 2017 Feb;61(1):34-39 - PubMed
- Physiologie. 1986 Apr-Jun;23(2):131-8 - PubMed
- Biochem Biophys Res Commun. 2012 May 18;421(4):837-43 - PubMed
- Hepatol Commun. 2019 Feb 08;3(4):493-503 - PubMed
- AIDS. 2019 Feb 1;33(2):269-278 - PubMed
- Medicine (Baltimore). 2017 Jun;96(26):e7266 - PubMed
- Iran J Radiol. 2015 Jan 01;12(1):e12708 - PubMed
- Rev Med Chil. 1985 Jul;113(7):661-4 - PubMed
- Eur J Clin Invest. 2008 Aug;38(8):571-7 - PubMed
- J Korean Med Sci. 2017 Feb;32(2):315-320 - PubMed
- Gastroenterology. 2018 Aug;155(2):411-421.e4 - PubMed
- World J Gastroenterol. 2020 Apr 7;26(13):1463-1473 - PubMed
- Dis Markers. 2013;35(6):915-23 - PubMed
- Radiology. 2004 Aug;232(2):420-30 - PubMed
- Korean J Intern Med. 2016 Jan;31(1):46-53 - PubMed
- Clin Exp Hepatol. 2019 Nov;5(4):317-326 - PubMed
- Radiology. 2014 Sep;272(3):635-54 - PubMed
- Egypt J Immunol. 2012;19(2):53-65 - PubMed
- Asian Pac J Cancer Prev. 2018 Apr 25;19(4):1021-1027 - PubMed
- Oncol Rep. 2010 Nov;24(5):1271-6 - PubMed
- J Ultrasound. 2009 Mar;12(1):12-21 - PubMed
- Aliment Pharmacol Ther. 2017 Jan;45(1):169-177 - PubMed
- Hepatology. 1990 Oct;12(4 Pt 1):680-7 - PubMed
- N Engl J Med. 1991 Sep 5;325(10):675-80 - PubMed
- Chin Med J (Engl). 2002 Jan;115(1):42-5 - PubMed
- J Comput Assist Tomogr. 2001 May-Jun;25(3):327-36 - PubMed
- World J Gastroenterol. 2015 Apr 7;21(13):3928-35 - PubMed
- Asian Pac J Cancer Prev. 2013;14(6):3819-23 - PubMed
- Gastroenterology. 1986 Feb;90(2):263-7 - PubMed
- Hepatol Int. 2009 Dec;3(4):544-50 - PubMed
- Hepatology. 1994 Jan;19(1):61-6 - PubMed
- Int J Infect Dis. 2018 Feb;67:92-97 - PubMed
- Ann Transplant. 2016 Oct 25;21:660-667 - PubMed
- Hepatology. 2014 Jul;60(1):408-18 - PubMed
- Tumour Biol. 2016 Jan;37(1):211-6 - PubMed
- Br J Cancer. 1997;75(10):1460-6 - PubMed
- Hepatol Int. 2011 Jun;5(2):698-706 - PubMed
- Hepatobiliary Pancreat Dis Int. 2013 Apr;12(2):171-9 - PubMed
- Hepatogastroenterology. 2009 Jul-Aug;56(93):1105-10 - PubMed
- Gastrointest Tumors. 2019 Feb;5(3-4):100-108 - PubMed
- Int J Biol Markers. 2004 Apr-Jun;19(2):155-9 - PubMed
- Eur J Cancer. 1998 Jul;34(8):1198-203 - PubMed
- J Gastroenterol. 2010 Dec;45(12):1272-82 - PubMed
- Clin Radiol. 1998 Oct;53(10):713-6 - PubMed
- Quad Sclavo Diagn. 1977 Sep;13(3):288-97 - PubMed
- Aliment Pharmacol Ther. 2013 Aug;38(3):303-12 - PubMed
- Hepatogastroenterology. 2014 Sep;61(134):1688-95 - PubMed
- Dig Surg. 2002;19(5):379-87; discussion 387-8 - PubMed
- Int J Technol Assess Health Care. 2003 Fall;19(4):591-603 - PubMed
- Br J Cancer. 1997;75(2):236-40 - PubMed
- Cancer Res Treat. 2020 Jul;52(3):789-797 - PubMed
- Tumour Biol. 2016 May;37(5):6539-49 - PubMed
- Ann Surg Oncol. 1999 Mar;6(2):178-85 - PubMed
- J Med Screen. 1999;6(2):108-10 - PubMed
- Gastroenterology. 2004 Apr;126(4):1005-14 - PubMed
- Radiology. 2000 Dec;217(3):743-9 - PubMed
- Clin Gastroenterol Hepatol. 2020 Mar;18(3):728-735.e4 - PubMed
- Clin Gastroenterol Hepatol. 2011 Feb;9(2):161-7 - PubMed
- Gastroenterology. 1994 Nov;107(5):1425-9 - PubMed
- Hepatology. 2018 Jan;67(1):401-421 - PubMed
- Gastroenterology. 2009 Jul;137(1):110-8 - PubMed
- Hepatology. 1985 Nov-Dec;5(6):1100-5 - PubMed
- Br J Biomed Sci. 2020 Apr;77(2):58-63 - PubMed
- Cochrane Database Syst Rev. 2017 Sep 18;9:CD012143 - PubMed
- Br J Cancer. 2015 Jan 6;112(1):69-76 - PubMed
- Oncotarget. 2016 Jan 26;7(4):3702-8 - PubMed
- J Am Coll Surg. 2012 Feb;214(2):174-83 - PubMed
- Hepatol Res. 2008;38(11):1098-111 - PubMed
- Tunis Med. 2007 May;85(5):421-6 - PubMed
- World J Gastroenterol. 2005 Nov 14;11(42):6607-12 - PubMed
- Oncology. 2007;72 Suppl 1:45-51 - PubMed
- Hepatology. 2007 Apr;45(4):948-56 - PubMed
- J Gastroenterol Hepatol. 1992 Jan-Feb;7(1):1-6 - PubMed
- J Med Screen. 2003;10(4):204-9 - PubMed
- Springerplus. 2013 Dec;2(1):69 - PubMed
- Hepatogastroenterology. 2013 Sep;60(126):1456-62 - PubMed
- Medicine (Baltimore). 2017 Mar;96(11):e5811 - PubMed
- Asian Pac J Cancer Prev. 2019 Aug 01;20(8):2515-2522 - PubMed
- Clin Oncol. 1984 Sep;10(3):241-6 - PubMed
- PLoS One. 2018 Jun 26;13(6):e0198937 - PubMed
- Dig Dis Sci. 1988 Jan;33(1):47-51 - PubMed
- Arab J Gastroenterol. 2014 Sep-Dec;15(3-4):103-7 - PubMed
- Int J Mol Med. 2002 Mar;9(3):245-50 - PubMed
- Medicine (Baltimore). 2015 Jun;94(23):e901 - PubMed
- World J Gastroenterol. 2005 Oct 21;11(39):6115-9 - PubMed
- J Proteome Res. 2010 Apr 5;9(4):1923-30 - PubMed
- Cancer Imaging. 2013 Feb 08;12:530-47 - PubMed
- Hepatogastroenterology. 2000 Nov-Dec;47(36):1654-8 - PubMed
- Anticancer Res. 2013 Mar;33(3):997-1001 - PubMed
- J Hepatol. 2012 Apr;56(4):908-43 - PubMed
- Br J Cancer. 2003 Jun 16;88(12):1878-82 - PubMed
- Hepatol Int. 2017 Jul;11(4):317-370 - PubMed
- J Clin Lab Anal. 2020 May;34(5):e23158 - PubMed
- Am J Gastroenterol. 2006 Mar;101(3):513-23 - PubMed
- East Afr Med J. 1980 Jun;57(6):382--9 - PubMed
- S Afr Med J. 1978 Mar 25;53(12):433-6 - PubMed
- Dis Markers. 2015;2015:707254 - PubMed
- Dis Markers. 2012;32(4):255-63 - PubMed
- EBioMedicine. 2015 Apr 13;2(6):604-12 - PubMed
- Gastroenterol Clin Biol. 2000 May;24(5 Pt 2):B92-4 - PubMed
- Cancer Epidemiol Biomarkers Prev. 2017 May;26(5):675-683 - PubMed
- PLoS One. 2016 Mar 17;11(3):e0151069 - PubMed
- Clin Biochem. 2010 Aug;43(12):1003-8 - PubMed
- Med Res Rev. 2018 Mar;38(2):741-767 - PubMed
- Eur Radiol. 2013 Apr;23(4):887-96 - PubMed
- Med J Malaysia. 2009 Sep;64(3):223-7 - PubMed
- Eur J Surg Oncol. 2013 Oct;39(10):1129-35 - PubMed
- Clin Radiol. 2006 Feb;61(2):191-7 - PubMed
- Oncol Lett. 2012 Oct;4(4):840-846 - PubMed
- Rinsho Byori. 1994 Oct;42(10):1036-42 - PubMed
- Korean J Gastroenterol. 2004 Apr;43(4):252-9 - PubMed
- Radiology. 2019 Aug;292(2):390-397 - PubMed
- World J Gastroenterol. 2013 Jan 21;19(3):339-46 - PubMed
- Br J Radiol. 2012 Oct;85(1018):1376-84 - PubMed
- Gut Liver. 2014 Mar;8(2):177-85 - PubMed
- Scand J Gastroenterol. 1993 Jun;28(6):540-4 - PubMed
- World J Gastroenterol. 2016 Sep 14;22(34):7806-12 - PubMed
- Dis Markers. 2019 Aug 14;2019:5945721 - PubMed
- J Gastroenterol. 2014 Mar;49(3):555-63 - PubMed
- Neoplasma. 2014;61(2):218-24 - PubMed
- J Clin Epidemiol. 2020 Jun;122:129-141 - PubMed
- Int J Cancer. 2020 Mar 15;146(6):1754-1763 - PubMed
- Liver Transpl Surg. 1995 Jul;1(4):249-55 - PubMed
- Cancer Biomark. 2007;3(2):79-87 - PubMed
- Liver. 1993 Aug;13(4):177-82 - PubMed
- Lancet Oncol. 2012 Aug;13(8):817-26 - PubMed
- AJR Am J Roentgenol. 2002 Jul;179(1):75-80 - PubMed
- Ann Surg Oncol. 2009 Oct;16(10):2795-804 - PubMed
- Clin Mol Hepatol. 2016 Sep;22(3):359-365 - PubMed
- Biochem Biophys Res Commun. 2012 Apr 6;420(2):308-14 - PubMed
- Hepatol Int. 2013 Oct;7(4):1050-7 - PubMed
- Asian Pac J Cancer Prev. 2010;11(4):897-903 - PubMed
- Oncol Lett. 2017 Jun;13(6):4208-4214 - PubMed
- Tumour Biol. 2015 Sep;36(10):7439-47 - PubMed
- J Coll Physicians Surg Pak. 2014 Jan;24(1):18-22 - PubMed
- Liver Int. 2008 Jan;28(1):79-87 - PubMed
- Hepatogastroenterology. 1995 Jul-Aug;42(4):387-93 - PubMed
- Arch Med Res. 2010 Oct;41(7):541-7 - PubMed
- World J Hepatol. 2018 Feb 27;10(2):267-276 - PubMed
- Ann Oncol. 2008 Feb;19(2):353-8 - PubMed
- Minerva Dietol Gastroenterol. 1988 Jul-Sep;34(3):163-6 - PubMed
- Int J Med Sci. 2014 Jan 07;11(2):164-71 - PubMed
- J Diabetes. 2016 Sep;8(5):640-6 - PubMed
- Ann Intern Med. 2015 May 19;162(10):697-711 - PubMed
- J Transl Int Med. 2020 May 09;8(1):32-40 - PubMed
- Radiol Med. 1988 Sep;76(3):187-92 - PubMed
- Clin Mol Hepatol. 2020 Jan;26(1):54-59 - PubMed
- Zhonghua Nei Ke Za Zhi. 1995 Oct;34(10):690-2 - PubMed
- Open Med (Wars). 2017 Oct 11;12:354-358 - PubMed
- Liver Transpl. 2011 Oct;17 Suppl 2:S44-57 - PubMed
- Cancer Control. 2005 Oct;12(4):248-53 - PubMed
- BMJ. 2008 May 17;336(7653):1106-10 - PubMed
- J Hepatol. 2012 Aug;57(2):330-6 - PubMed
- Ultrasonography. 2015 Jan;34(1):3-18 - PubMed
- Swiss Med Wkly. 2015 Nov 20;145:w14200 - PubMed
- Ultrasound Q. 2016 Dec;32(4):319-326 - PubMed
- JAMA. 1985 Dec 6;254(21):3052-4 - PubMed
- Tumori. 1995 Mar-Apr;81(2):86-90 - PubMed
- BMJ. 2012 Oct 24;345:e6717 - PubMed
- J Gastrointest Cancer. 2018 Dec;49(4):476-480 - PubMed
- Cancer Epidemiol Biomarkers Prev. 2008 Jul;17(7):1813-21 - PubMed
- Anal Bioanal Chem. 2011 Oct;401(6):1899-904 - PubMed
- Am J Gastroenterol. 2000 Jun;95(6):1535-8 - PubMed
- Indian J Cancer. 2008 Oct-Dec;45(4):167-72 - PubMed
- BMC Cancer. 2007 Feb 08;7:28 - PubMed
- Scand J Gastroenterol. 2019 Oct;54(10):1283-1290 - PubMed
- Sci Rep. 2017 Aug 25;7(1):9449 - PubMed
- Cancer Prev Res (Phila). 2016 Feb;9(2):172-9 - PubMed
- Neoplasma. 2017;64(5):745-753 - PubMed
- J Surg Oncol. 2007 Jun 15;95(8):645-51 - PubMed
- Int J Clin Oncol. 2017 Apr;22(2):332-339 - PubMed
- Cancer Sci. 2017 Jul;108(7):1432-1439 - PubMed
- BMC Gastroenterol. 2018 Dec 13;18(1):186 - PubMed
- Infect Agent Cancer. 2017 Aug 23;12:47 - PubMed
- Cancer. 1983 Jun 1;51(11):2112-5 - PubMed
- Hepatol Res. 2010 May;40(5):477-85 - PubMed
- N Engl J Med. 1996 Mar 14;334(11):693-9 - PubMed
- Biosci Trends. 2014 Oct;8(5):266-73 - PubMed
- J Ultrasound Med. 2001 Feb;20(2):99-104 - PubMed
- Semin Oncol. 2012 Aug;39(4):399-409 - PubMed
- Medicine (Baltimore). 2020 May;99(20):e20326 - PubMed
- Int J Cancer. 2010 Jul 1;127(1):148-59 - PubMed
- Acta Med Indones. 2015 Jul;47(3):216-22 - PubMed
- Int J Cancer. 2015 Jan 1;136(1):172-81 - PubMed
- J Clin Lab Anal. 2011;25(5):350-3 - PubMed
- N Engl J Med. 1993 Jun 24;328(25):1802-6 - PubMed
- Am J Gastroenterol. 2006 Sep;101(9):2051-9 - PubMed
- Int J Cancer. 2009 Jun 15;124(12):2766-70 - PubMed
- Gastroenterol Hepatol Bed Bench. 2017 Spring;10(2):97-101 - PubMed
- Ann Hepatol. 2015 Nov-Dec;14(6):882-8 - PubMed
- J Gastroenterol Hepatol. 2014 Mar;29(3):597-602 - PubMed
- Hepatobiliary Pancreat Dis Int. 2008 Jun;7(3):288-95 - PubMed
- Med Oncol. 2015 Jan;32(1):432 - PubMed
- Am J Physiol Gastrointest Liver Physiol. 2020 Feb 1;318(2):G305-G312 - PubMed
- BMC Gastroenterol. 2019 Oct 21;19(1):167 - PubMed
- J Hepatol. 2005 Sep;43(3):434-41 - PubMed
- Saudi Med J. 2005 Jun;26(6):974-7 - PubMed
- Gastroenterology Res. 2013 Oct;6(5):191-199 - PubMed
- J Viral Hepat. 2017 Jan;24(1):80-85 - PubMed
- Clin Chim Acta. 2007 Aug;383(1-2):147-52 - PubMed
- Tohoku J Exp Med. 2014;232(3):187-94 - PubMed
- Curr Genomics. 2020 Jan;21(1):46-55 - PubMed
- Sci Rep. 2017 Oct 30;7(1):14352 - PubMed
- Eur J Gastroenterol Hepatol. 2003 Aug;15(8):893-900 - PubMed
- Med Oncol. 2015 Mar;32(3):59 - PubMed
- Gastroenterology. 2018 May;154(6):1706-1718.e1 - PubMed
- Arab J Gastroenterol. 2014 Jun;15(2):68-71 - PubMed
- J Hepatol. 2018 Jul;69(1):182-236 - PubMed
- Dis Markers. 2011;30(6):307-15 - PubMed
- Hepat Mon. 2015 Sep 01;15(9):e30753 - PubMed
- J Gastroenterol Hepatol. 2011 Apr;26(4):739-44 - PubMed
- Dig Dis Sci. 1991 Dec;36(12):1787-92 - PubMed
- Biull Eksp Biol Med. 1971 Apr;71(4):75-81 - PubMed
- J Immunoassay Immunochem. 2016;37(3):273-88 - PubMed
- Hepatogastroenterology. 2013 Sep;60(126):1245-50 - PubMed
- Ann Biol Clin (Paris). 1998 Mar-Apr;56(2):175-81 - PubMed
- Blood. 1998 Feb 15;91(4):1173-7 - PubMed
- Asian Pac J Cancer Prev. 2018 Jun 25;19(6):1503-1508 - PubMed
- J Int Med Res. 2020 Mar;48(3):300060519889270 - PubMed
- BMC Gastroenterol. 2015 Sep 04;15:113 - PubMed
- Int J Cancer. 2005 Nov 10;117(3):506-9 - PubMed
- Arab J Gastroenterol. 2012 Jun;13(2):49-53 - PubMed
- Virus Res. 2018 Aug 15;255:77-84 - PubMed
- BMC Cancer. 2019 Nov 12;19(1):1088 - PubMed
- Neoplasma. 2016;63(3):419-26 - PubMed
- J Cancer Res Ther. 2018 Oct-Dec;14(6):1239-1244 - PubMed
- Open Access Maced J Med Sci. 2015 Mar 15;3(1):117-23 - PubMed
- J Gastroenterol Hepatol. 2003 Mar;18(3):288-95 - PubMed
- Br J Cancer. 1995 Aug;72(2):442-6 - PubMed
- Int J Biol Markers. 1988 Jul-Sep;3(3):172-6 - PubMed
- Biomark Med. 2019 May;13(7):545-555 - PubMed
- J Hepatol. 2015 Apr;62(4):848-54 - PubMed
- Clin Lab. 2016;62(6):1121-9 - PubMed
- Cancer Manag Res. 2019 Nov 05;11:9379-9386 - PubMed
- Hepatol Int. 2010 Jul 13;4(3):569-76 - PubMed
- Int J Cancer. 2002 Mar 10;98(2):257-61 - PubMed
- World J Hepatol. 2015 Mar 27;7(3):406-24 - PubMed
- Cancer Med. 2020 May;9(9):3057-3069 - PubMed
- Hepatology. 2007 Nov;46(5):1426-35 - PubMed
- Hepatol Res. 2014 Oct;44(10):E11-25 - PubMed
- Ital J Gastroenterol. 1993 Jan;25(1):9-12 - PubMed
- J Formos Med Assoc. 1995 Dec;94 Suppl 2:S94-102 - PubMed
- AJR Am J Roentgenol. 2004 Aug;183(2):453-8 - PubMed
- Eur J Gastroenterol Hepatol. 2015 Mar;27(3):355-60 - PubMed
- Int J Biol Markers. 2013 Sep 27;28(3):286-97 - PubMed
- Turk J Gastroenterol. 2016 Jul;27(4):375-81 - PubMed
- PLoS One. 2016 May 24;11(5):e0155800 - PubMed
- Clin Res Hepatol Gastroenterol. 2016 Sep;40(4):397-404 - PubMed
- J Clin Epidemiol. 2016 Aug;76:89-98 - PubMed
- Z Gastroenterol. 2016 Dec;54(12):1296-1305 - PubMed
- Acta Med Indones. 2019 Apr;51(2):137-144 - PubMed
- PLoS One. 2016 Apr 12;11(4):e0153227 - PubMed
- Cancer Lett. 2010 Mar 1;289(1):32-9 - PubMed
- Hepatology. 1995 Aug;22(2):432-8 - PubMed
- Clin Cancer Res. 2008 Jan 15;14(2):470-7 - PubMed
- Clin Chim Acta. 1995 Apr 30;236(1):71-9 - PubMed
- Rev Esp Enferm Apar Dig. 1987 Dec;72(6):701-4 - PubMed
- Hepatology. 2019 May;69(5):1983-1994 - PubMed
- Am J Gastroenterol. 1996 Jul;91(7):1380-3 - PubMed
- Gastroenterology. 2015 Sep;149(3):649-59 - PubMed
- Radiographics. 2019 May-Jun;39(3):690-708 - PubMed
- Arab J Gastroenterol. 2012 Mar;13(1):9-13 - PubMed
- Am J Gastroenterol. 2015 Jun;110(6):836-44; quiz 845 - PubMed
- Cancer Manag Res. 2018 Jul 10;10:1947-1958 - PubMed
- Clin Chem. 2019 Dec;65(12):1543-1553 - PubMed
- Technol Cancer Res Treat. 2018 Jan 1;17:1533033818794494 - PubMed
- Hepatology. 2018 Jan;67(1):358-380 - PubMed
- Gastroenterology. 1971 Aug;61(2):137-43 - PubMed
- Clin Chim Acta. 2013 Aug 23;423:105-11 - PubMed
- Cancer Sci. 2011 May;102(5):1025-31 - PubMed
- J Hepatol. 2005 Dec;43(6):1007-12 - PubMed
- Br J Cancer. 2013 Sep 17;109(6):1657-65 - PubMed
- Dig Dis Sci. 1995 Dec;40(12):2587-94 - PubMed
- Rinsho Hoshasen. 1979 Jul;24(7):729-37 - PubMed
- J Gastroenterol Hepatol. 2010 Jan;25(1):129-37 - PubMed
- Cancer. 2002 Jan 1;94(1):175-80 - PubMed
- Oncotarget. 2017 Mar 8;8(46):81235-81249 - PubMed
- Am J Gastroenterol. 1999 Oct;94(10):2988-93 - PubMed
- J Gastroenterol Hepatol. 2000 Apr;15(4):417-21 - PubMed
- Cancer. 1977 Aug;40(2):779-83 - PubMed
- J Gastroenterol Hepatol. 2008 Oct;23(10):1541-8 - PubMed
- Arab J Gastroenterol. 2020 Jun;21(2):80-84 - PubMed
- Open Life Sci. 2019 Mar 20;14:53-61 - PubMed
- Am J Gastroenterol. 1999 Mar;94(3):650-4 - PubMed
- PLoS One. 2017 Sep 13;12(9):e0183880 - PubMed
- J Clin Exp Hepatol. 2014 Aug;4(Suppl 3):S63-6 - PubMed
- J Hepatobiliary Pancreat Surg. 2006;13(3):239-44 - PubMed
- J Proteome Res. 2010 Feb 5;9(2):798-805 - PubMed
- Eur Radiol. 2003 Jul;13(7):1693-8 - PubMed
- Cancers (Basel). 2019 Oct 06;11(10): - PubMed
- Clin Chim Acta. 2000 Jun;296(1-2):181-91 - PubMed
- Scand J Gastroenterol. 1982 Oct;17(7):897-903 - PubMed
- J Ayub Med Coll Abbottabad. 2009 Jan-Mar;21(1):72-5 - PubMed
- Hepatology. 2000 Oct;32(4 Pt 1):842-6 - PubMed
- J Gastroenterol Hepatol. 2014;29(7):1544-50 - PubMed
- Glycoconj J. 2020 Apr;37(2):231-240 - PubMed
- Dig Dis Sci. 2016 Apr;61(4):1130-8 - PubMed
- Cancer Lett. 2016 Apr 10;373(2):234-40 - PubMed
- Transplant Proc. 2001 Feb-Mar;33(1-2):1854-5 - PubMed
- Hepatogastroenterology. 1988 Jun;35(3):101-3 - PubMed
- Liver Cancer. 2019 Jul;8(4):271-280 - PubMed
- Cancer Manag Res. 2019 Jul 29;11:7159-7169 - PubMed
- Medicine (Baltimore). 2019 Mar;98(9):e14749 - PubMed
- Radiographics. 2002 Sep-Oct;22(5):1023-36; discussion 1037-9 - PubMed
- Eur J Gastroenterol Hepatol. 1999 Dec;11(12):1387-92 - PubMed
- BMC Cancer. 2015 Dec 18;15:985 - PubMed
- Clin Gastroenterol Hepatol. 2011 Jul;9(7):617-23.e1 - PubMed
- BMC Gastroenterol. 2015 Jun 30;15:73 - PubMed
- Radiology. 2003 Feb;226(2):533-42 - PubMed
- J Natl Cancer Inst. 2008 May 21;100(10):698-711 - PubMed
- AJR Am J Roentgenol. 1992 Oct;159(4):727-33 - PubMed
- Digestion. 1977;16(1-2):118-27 - PubMed
- Metabolites. 2012 Oct 10;2(4):701-16 - PubMed
- Tunis Med. 1985 Mar;63(3):237-40 - PubMed
- Clin Chim Acta. 1988 Dec 15;178(2):151-8 - PubMed
- Hepatogastroenterology. 2011 Sep-Oct;58(110-111):1718-24 - PubMed
- CA Cancer J Clin. 2018 Nov;68(6):394-424 - PubMed
- J Gastroenterol Hepatol. 2009 Jan;24(1):55-62 - PubMed
- Scand J Gastroenterol. 2009;44(7):861-6 - PubMed
- Clin Gastroenterol Hepatol. 2007 Mar;5(3):394-402; quiz 267 - PubMed
- Oncology. 2007;72 Suppl 1:117-23 - PubMed
- Liver Cancer. 2017 Jun;6(3):189-203 - PubMed
- Cancer Sci. 2013 Jun;104(6):725-31 - PubMed
- Hepatology. 2012 Feb;55(2):483-90 - PubMed
- East Mediterr Health J. 2016 Nov 02;22(8):603-610 - PubMed
- Liver Transpl. 2002 Sep;8(9):749-61 - PubMed
- Hepatology. 2011 Mar;53(3):1020-2 - PubMed
- Sci Rep. 2016 Oct 12;6:35050 - PubMed
- Cancer Biomark. 2013;13(5):351-7 - PubMed
- Cancer Manag Res. 2018 Nov 20;10:5979-5989 - PubMed
- Zhonghua Gan Zang Bing Za Zhi. 2012 Oct;20(10):785-8 - PubMed
- Hepatology. 1996 May;23(5):1112-8 - PubMed
- Ann Surg. 1998 Apr;227(4):513-8 - PubMed
- Genet Mol Res. 2015 Dec 21;14(4):17453-62 - PubMed
- Stat Med. 2001 Oct 15;20(19):2865-84 - PubMed
- PLoS One. 2014 Jul 17;9(7):e100187 - PubMed
- Hepatol Res. 2011 Dec;41(12):1199-207 - PubMed
- Radiology. 1983 May;147(2):517-9 - PubMed
- Digestion. 2013;87(2):121-31 - PubMed
- Asian Pac J Cancer Prev. 2015;16(16):7211-7 - PubMed
- Am J Gastroenterol. 2012 Jan;107(1):64-74 - PubMed
- Oncol Lett. 2018 Dec;16(6):7123-7130 - PubMed
- Int J Mol Sci. 2019 Feb 17;20(4): - PubMed
- World J Gastroenterol. 2019 Sep 28;25(36):5515-5529 - PubMed
- Cancer Epidemiol Biomarkers Prev. 2009 Jun;18(6):1914-21 - PubMed
- Hepatol Res. 2016 Mar;46(3):E130-5 - PubMed
- Int J Clin Oncol. 2012 Aug;17(4):373-9 - PubMed
- Panminerva Med. 2017 Dec;59(4):283-289 - PubMed
- Oncotarget. 2017 Jul 11;8(28):46234-46248 - PubMed
- Med Sci Monit. 2016 May 17;22:1663-72 - PubMed
- Niger J Med. 2006 Oct-Dec;15(4):417-20 - PubMed
- Ann Hepatol. 2011 Jul-Sep;10(3):296-305 - PubMed
- Clin Proteomics. 2019 Jan 16;16:2 - PubMed
- J Hepatol. 2015 Sep;63(3):743-52 - PubMed
- Hepatology. 2017 Apr;65(4):1196-1205 - PubMed
- Korean J Gastroenterol. 2006 Nov;48(5):321-6 - PubMed
- Clin Chem Lab Med. 2011 Apr;49(4):711-8 - PubMed
- HPB (Oxford). 2019 Jun;21(6):731-738 - PubMed
- Gut. 2010 Dec;59(12):1687-93 - PubMed
- Lancet. 2003 Dec 6;362(9399):1907-17 - PubMed
- In Vivo. 2017 Jul-Aug;31(4):695-700 - PubMed
- J BUON. 2019 Jul-Aug;24(4):1429-1434 - PubMed
- Arch Iran Med. 2013 Jun;16(6):348-50 - PubMed
- Hepatogastroenterology. 1989 Dec;36(6):519-21 - PubMed
- J Viral Hepat. 2018 Jan;25(1):47-55 - PubMed
- Hepatology. 2016 May;63(5):1430-41 - PubMed
- J Egypt Natl Canc Inst. 2014 Jun;26(2):79-85 - PubMed
- Am J Gastroenterol. 2006 Sep;101(9):2038-43 - PubMed
- Asian Pac J Cancer Prev. 2019 Sep 01;20(9):2723-2731 - PubMed
- Medicine (Baltimore). 2019 Apr;98(17):e15414 - PubMed
- Clin Gastroenterol Hepatol. 2014 May;12(5):870-7 - PubMed
- J Gastrointest Cancer. 2020 Mar;51(1):234-241 - PubMed
- J Hepatol. 2001 Apr;34(4):570-5 - PubMed
- Cancer. 1998 May 1;82(9):1643-8 - PubMed
- Cancer. 2001 Feb 1;91(3):561-9 - PubMed
- Ann Gastroenterol Hepatol (Paris). 1992 Oct;28(5):213-6 - PubMed
- Clin Chim Acta. 1988 Apr 15;173(2):157-64 - PubMed
- Clin Res Hepatol Gastroenterol. 2017 Mar;41(2):171-180 - PubMed
- Hepat Mon. 2014 Sep 24;14(9):e19346 - PubMed
- Hepatology. 2002 Aug;36(2):410-7 - PubMed
- Clin Cancer Res. 2013 Jul 15;19(14):3944-54 - PubMed
- Ann Transplant. 2016 Feb 18;21:115-24 - PubMed
- Cancer. 1991 Oct 15;68(8):1795-8 - PubMed
- Abdom Imaging. 1995 Nov-Dec;20(6):547-53 - PubMed
- J Transl Med. 2018 Jun 28;16(1):177 - PubMed
- Cancer. 1986 Jul 15;58(2):344-7 - PubMed
- PLoS One. 2013 Jul 18;8(7):e68904 - PubMed
- Gut. 1997 Sep;41(3):404-7 - PubMed
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