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Harmand MF, Vilamitjana J, Maloche E, et al. Effects of S-adenosylmethionine on human articular chondrocyte differentiation. An in vitro study. Am J Med. 1987;83(5):48-54doi: 10.1016/0002-9343(87)90851-5.
Harmand, M. F., Vilamitjana, J., Maloche, E., Duphil, R., & Ducassou, D. (1987). Effects of S-adenosylmethionine on human articular chondrocyte differentiation. An in vitro study. The American journal of medicine, 83(5), 48-54. https://doi.org/10.1016/0002-9343(87)90851-5
Harmand, M F, et al. "Effects of S-adenosylmethionine on human articular chondrocyte differentiation. An in vitro study." The American journal of medicine vol. 83,5 (1987): 48-54. doi: https://doi.org/10.1016/0002-9343(87)90851-5
Harmand MF, Vilamitjana J, Maloche E, Duphil R, Ducassou D. Effects of S-adenosylmethionine on human articular chondrocyte differentiation. An in vitro study. Am J Med. 1987 Nov 20;83(5):48-54. doi: 10.1016/0002-9343(87)90851-5. PMID: 3120586.
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Am J Med. 1987 Nov 20;83(5):48-54. doi: 10.1016/0002-9343(87)90851-5.

Effects of S-adenosylmethionine on human articular chondrocyte differentiation. An in vitro study.

The American journal of medicine

M F Harmand, J Vilamitjana, E Maloche, R Duphil, D Ducassou

Affiliations

  1. Inserm U. 306, Université de Bordeaux II, France.

PMID: 3120586 DOI: 10.1016/0002-9343(87)90851-5

Abstract

The effect of S-adenosyl-L-methionine (SAMe) on human articular osteoarthritic chondrocytes was studied using a thick-layer culture model. Three SAMe concentrations were tested (1, 10, and 100 micrograms/ml). For 10 micrograms/ml, the most efficient dose, a significant rise in the incorporation levels of 35S-sulfate and 3H-serine was observed, as was as an increase in the hexuronic acid content. All the parameters seem to express a more active protein synthesis, particularly for proteoglycans. Under the same conditions, the proliferation rate of chondrocytes does not undergo important variations. These results point to a direct action on the cell metabolism but little is known concerning the mechanism involved.

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