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Delay L, Gonçalves Dos Santos G, Dias EV, et al. Sexual Dimorphism in the Expression of Pain Phenotype in Preclinical Models of Rheumatoid Arthritis. Rheum Dis Clin North Am. 2021;47(2):245-264doi: 10.1016/j.rdc.2020.12.006.
Delay, L., Gonçalves Dos Santos, G., Dias, E. V., Yaksh, T. L., & Corr, M. (2021). Sexual Dimorphism in the Expression of Pain Phenotype in Preclinical Models of Rheumatoid Arthritis. Rheumatic diseases clinics of North America, 47(2), 245-264. https://doi.org/10.1016/j.rdc.2020.12.006
Delay, Lauriane, et al. "Sexual Dimorphism in the Expression of Pain Phenotype in Preclinical Models of Rheumatoid Arthritis." Rheumatic diseases clinics of North America vol. 47,2 (2021): 245-264. doi: https://doi.org/10.1016/j.rdc.2020.12.006
Delay L, Gonçalves Dos Santos G, Dias EV, Yaksh TL, Corr M. Sexual Dimorphism in the Expression of Pain Phenotype in Preclinical Models of Rheumatoid Arthritis. Rheum Dis Clin North Am. 2021 May;47(2):245-264. doi: 10.1016/j.rdc.2020.12.006. Epub 2021 Feb 26. PMID: 33781493; PMCID: PMC8015200.
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Rheum Dis Clin North Am. 2021 May;47(2):245-264. doi: 10.1016/j.rdc.2020.12.006. Epub 2021 Feb 26.

Sexual Dimorphism in the Expression of Pain Phenotype in Preclinical Models of Rheumatoid Arthritis.

Rheumatic diseases clinics of North America

Lauriane Delay, Gilson Gonçalves Dos Santos, Elayne Vieira Dias, Tony L Yaksh, Maripat Corr

Affiliations

  1. Department of Anesthesiology, University of California San Diego, 9500 Gilman Dr., La Jolla, CA 92093, USA. Electronic address: [email protected].
  2. Department of Anesthesiology, University of California San Diego, 9500 Gilman Dr., La Jolla, CA 92093, USA.
  3. Division of Rheumatology, Allergy and Immunology, University of California San Diego, 9500 Gilman Dr., La Jolla, CA 92093, USA.

PMID: 33781493 PMCID: PMC8015200 DOI: 10.1016/j.rdc.2020.12.006

Abstract

Rheumatoid arthritis is one of most frequent rheumatic diseases, affecting around 1% of the population worldwide. Pain impacting the quality of life for the patient with rheumatoid arthritis, is often the primary factor leading them to seek medical care. Although sex-related differences in humans and animal models of rheumatoid arthritis are described, the correlation between pain and sex in rheumatoid arthritis has only recently been directly examined. Here we review the literature and explore the mechanisms underlying the expression of the pain phenotype in females and males in preclinical models of rheumatoid arthritis.

Published by Elsevier Inc.

Keywords: Pain; Rheumatoid arthritis; Sexual dimorphism

Conflict of interest statement

Disclosure The authors receive grant support from United States, NIH/NINDS 1 R01 NS099338 and 1 R01 NS102432-01.

References

  1. World Health Organ Tech Rep Ser. 2003;919:i-x, 1-218, back cover - PubMed
  2. Anesth Analg. 2008 Jul;107(1):309-17 - PubMed
  3. Arthritis Rheumatol. 2017 Jun;69(6):1165-1175 - PubMed
  4. Ann Rheum Dis. 2011 Mar;70(3):508-11 - PubMed
  5. J Pain. 2009 May;10(5):447-85 - PubMed
  6. Arthritis Rheum. 2010 Jun;62(6):1620-9 - PubMed
  7. Nat Rev Rheumatol. 2016 Jun;12(6):335-43 - PubMed
  8. Biol Reprod. 2001 Jan;64(1):331-8 - PubMed
  9. Ann Rheum Dis. 2017 Jul;76(7):1184-1190 - PubMed
  10. Nat Genet. 2012 Jan 29;44(3):291-6 - PubMed
  11. Pharmacol Biochem Behav. 2017 Jan;152:30-35 - PubMed
  12. Clin Exp Rheumatol. 2017 May-Jun;35(3):368-378 - PubMed
  13. J Pharmacol Exp Ther. 2020 Oct;375(1):202-209 - PubMed
  14. Int J Mol Sci. 2014 Dec 03;15(12):22279-95 - PubMed
  15. Brain Behav Immun. 2019 Feb;76:151-158 - PubMed
  16. Ann Rheum Dis. 2016 Apr;75(4):730-8 - PubMed
  17. Arthritis Rheum. 1987 Nov;30(11):1205-13 - PubMed
  18. J Rheumatol. 2015 Sep;42(9):1563-9 - PubMed
  19. Pain. 2018 Sep;159 Suppl 1:S98-S109 - PubMed
  20. Arthritis Rheumatol. 2015 Mar;67(3):645-55 - PubMed
  21. Nat Neurosci. 2015 Aug;18(8):1081-3 - PubMed
  22. Eur J Epidemiol. 2018 Apr;33(4):415-423 - PubMed
  23. Neurosci Lett. 2004 May 6;361(1-3):176-9 - PubMed
  24. Neuroreport. 1998 Dec 21;9(18):4137-40 - PubMed
  25. Ann Rheum Dis. 2013 Aug;72(8):1420-4 - PubMed
  26. Proc Natl Acad Sci U S A. 2011 Oct 18;108(42):17372-7 - PubMed
  27. Arthritis Res Ther. 2015 Nov 24;17:339 - PubMed
  28. Ann Ist Super Sanita. 2016 Apr-Jun;52(2):205-12 - PubMed
  29. Immunopharmacol Immunotoxicol. 2018 Jun;40(3):193-200 - PubMed
  30. J Med Food. 2018 Jan;21(1):39-46 - PubMed
  31. J Pharmacol Exp Ther. 2005 Apr;313(1):449-59 - PubMed
  32. Arthritis Res Ther. 2013;15 Suppl 3:S2 - PubMed
  33. Pain. 2010 Nov;151(2):394-403 - PubMed
  34. Cell. 1996 Nov 29;87(5):811-22 - PubMed
  35. Arthritis Rheum. 2010 Nov;62(11):3161-72 - PubMed
  36. Ann Rheum Dis. 2014 Jul;73(7):1316-22 - PubMed
  37. Curr Microbiol. 2013 Aug;67(2):170-6 - PubMed
  38. Rheumatology (Oxford). 2017 Aug 1;56(8):1254-1263 - PubMed
  39. Semin Immunopathol. 2017 Jun;39(4):395-408 - PubMed
  40. Endocrinology. 2013 Jul;154(7):2421-33 - PubMed
  41. Mediterr J Rheumatol. 2017 Dec 22;28(4):223-226 - PubMed
  42. J Neurosci Methods. 2003 Sep 30;128(1-2):45-52 - PubMed
  43. Annu Rev Neurosci. 2017 Jul 25;40:307-325 - PubMed
  44. Clin Rheumatol. 2016 Dec;35(12):2983-2987 - PubMed
  45. Nat Rev Neurosci. 2020 Jul;21(7):353-365 - PubMed
  46. Front Neuroendocrinol. 2013 Oct;34(4):350-66 - PubMed
  47. Neurosignals. 2005;14(4):147-57 - PubMed
  48. Curr Opin Rheumatol. 2018 May;30(3):282-287 - PubMed
  49. RMD Open. 2018 Jan 12;4(1):e000256 - PubMed
  50. Endocrinology. 2008 Nov;149(11):5540-8 - PubMed
  51. Front Immunol. 2020 Jan 28;10:3061 - PubMed
  52. Am J Med. 2006 Jun;119(6):503.e1-9 - PubMed
  53. Rheumatology (Oxford). 2017 Oct 1;56(10):1794-1803 - PubMed
  54. Ann Rheum Dis. 2019 Nov;78(11):1497-1504 - PubMed
  55. Arthritis Rheum. 2007 Dec;56(12):4015-23 - PubMed
  56. Elife. 2013 Nov 05;2:e01202 - PubMed
  57. Front Immunol. 2018 Apr 17;9:794 - PubMed
  58. J Clin Invest. 2012 May;122(5):1791-802 - PubMed
  59. Pain. 2020 Dec;161(12):2898-2908 - PubMed
  60. J Neurosci. 1994 Jun;14(6):3725-35 - PubMed
  61. Brain Res Bull. 1988 Dec;21(6):947-53 - PubMed
  62. Pain. 2018 Sep;159(9):1752-1763 - PubMed
  63. Brain Res. 1998 Apr 27;791(1-2):35-42 - PubMed
  64. Nature. 2014 Feb 20;506(7488):376-81 - PubMed
  65. Sci Rep. 2020 Jan 27;10(1):1214 - PubMed
  66. J Neuroendocrinol. 2012 May;24(5):789-97 - PubMed
  67. J Neurosci. 1994 Feb;14(2):459-71 - PubMed
  68. Nat Rev Rheumatol. 2017 Feb;13(2):79-86 - PubMed
  69. Ann Rheum Dis. 2005 Apr;64(4):582-6 - PubMed
  70. Sci Transl Med. 2013 Mar 27;5(178):178ra40 - PubMed
  71. Am J Physiol Regul Integr Comp Physiol. 2006 Aug;291(2):R241-4 - PubMed
  72. Arthritis Res Ther. 2013 Apr 22;15(2):R56 - PubMed
  73. J Int Med Res. 2010 Jul-Aug;38(4):1213-24 - PubMed
  74. Eur J Immunol. 2016 Dec;46(12):2862-2870 - PubMed
  75. Best Pract Res Clin Rheumatol. 2017 Feb;31(1):3-18 - PubMed
  76. Biol Psychiatry. 2020 Oct 5;: - PubMed
  77. Sci Rep. 2016 May 18;6:26021 - PubMed
  78. Nat Rev Rheumatol. 2014 Dec;10(12):740-51 - PubMed
  79. J Pharmacol Pharmacother. 2017 Jul-Sep;8(3):81-86 - PubMed
  80. Ann Rheum Dis. 2012 Mar;71(3):424-31 - PubMed
  81. Arthritis Rheumatol. 2014 Mar;66(3):513-22 - PubMed
  82. Nat Rev Dis Primers. 2018 Feb 08;4:18001 - PubMed
  83. Rheumatology (Oxford). 2018 Aug 1;57(8):1453-1460 - PubMed
  84. J Rheumatol. 2008 Aug;35(8):1500-5 - PubMed
  85. J Neurosci Methods. 2004 Oct 30;139(2):281-91 - PubMed
  86. Trends Pharmacol Sci. 2018 Dec;39(12):1000-1002 - PubMed
  87. Methods Mol Biol. 2012;851:249-60 - PubMed
  88. Semin Arthritis Rheum. 2005 Feb;34(4):662-7 - PubMed
  89. Klin Med (Mosk). 2011;89(4):45-8 - PubMed
  90. Pain. 2019 Jan;160(1):224-236 - PubMed
  91. J Pain. 2007 May;8(5):437-42 - PubMed
  92. J Pain. 2006 Apr;7(4):281-9 - PubMed
  93. Arthritis Res Ther. 2014 Jun 13;16(3):R122 - PubMed
  94. iScience. 2019 Oct 25;20:449-465 - PubMed
  95. Am J Physiol Regul Integr Comp Physiol. 2006 Aug;291(2):R327-34 - PubMed
  96. Rheumatol Ther. 2019 Sep;6(3):461-471 - PubMed
  97. Brain Res Bull. 2005 Aug 15;66(3):179-88 - PubMed
  98. Ann Rheum Dis. 2013 Jun;72(6):949-54 - PubMed
  99. Eur J Pain. 2014 Jan;18(1):39-46 - PubMed
  100. Arthritis Rheum. 2004 Feb;50(2):380-6 - PubMed
  101. Arthritis Res Ther. 2020 Jul 2;22(1):165 - PubMed
  102. Rev Pain. 2008 Dec;2(2):20-4 - PubMed
  103. Purinergic Signal. 2011 Mar;7(1):73-83 - PubMed
  104. Arthritis Res Ther. 2011 Jun 08;13(3):R83 - PubMed
  105. Curr Opin Rheumatol. 2018 Mar;30(2):188-196 - PubMed
  106. Pharmacol Biochem Behav. 1988 Apr;29(4):705-9 - PubMed
  107. Arthritis Rheum. 1992 Aug;35(8):914-7 - PubMed
  108. Exp Neurol. 1999 Feb;155(2):260-7 - PubMed
  109. Andrologia. 2020 Oct;52(9):e13768 - PubMed
  110. Rheumatology (Oxford). 2016 Dec;55(12):2248-2259 - PubMed
  111. Pain. 2016 Feb;157 Suppl 1:S2-S6 - PubMed
  112. Reumatismo. 2014 Jun 06;66(1):18-27 - PubMed
  113. Pain Manag. 2016;6(3):265-84 - PubMed
  114. Cereb Cortex. 2013 Sep;23(9):2190-203 - PubMed
  115. J Neurosci. 2011 Oct 26;31(43):15450-4 - PubMed
  116. Nat Rev Rheumatol. 2014 Oct;10(10):581-92 - PubMed
  117. Sci Rep. 2016 Jan 29;6:20059 - PubMed
  118. Pain. 2007 Nov;132 Suppl 1:S26-S45 - PubMed
  119. Arthritis Rheum. 2011 Nov;63(11):3226-33 - PubMed
  120. Arthritis Res Ther. 2016 May 04;18(1):97 - PubMed
  121. Arthritis Res Ther. 2017 Jun 30;19(1):146 - PubMed
  122. Front Immunol. 2017 Jun 23;8:720 - PubMed
  123. Database (Oxford). 2015 Apr 15;2015:bav028 - PubMed
  124. Int J Mol Sci. 2016 Nov 08;17(11): - PubMed
  125. Ann Oncol. 2018 Feb 1;29(2):386-391 - PubMed
  126. Clin Exp Rheumatol. 2017 Sep-Oct;35 Suppl 107(5):94-101 - PubMed
  127. Ann Rheum Dis. 2015 Jan;74(1):234-41 - PubMed
  128. Arthritis Rheum. 2010 Feb;62(2):383-91 - PubMed
  129. Neuroreport. 2012 Jun 20;23(9):530-4 - PubMed
  130. Ann Rheum Dis. 1992 Aug;51(8):1014-8 - PubMed
  131. Pain Ther. 2017 Dec;6(2):111-114 - PubMed
  132. Epigenomics. 2017 Apr;9(4):479-492 - PubMed
  133. Nat Med. 2015 Aug;21(8):895-905 - PubMed
  134. Ann Rheum Dis. 2014 Apr;73(4):780-3 - PubMed
  135. PLoS One. 2017 Apr 25;12(4):e0175737 - PubMed
  136. Biomed Pharmacother. 2020 Sep;129:110447 - PubMed
  137. Neuroscience. 2016 Dec 3;338:63-80 - PubMed
  138. Arthritis Rheum. 1977 Jun;20(5):1037-42 - PubMed
  139. Rheum Dis Clin North Am. 2010 May;36(2):213-41 - PubMed
  140. J Neurosci Res. 2011 Nov;89(11):1707-10 - PubMed
  141. Arthritis Rheum. 2006 Oct;54(10):3087-94 - PubMed
  142. Arthritis Rheum. 2013 Nov;65(11):2773-82 - PubMed
  143. Semin Arthritis Rheum. 2010 Oct;40(2):109-26 - PubMed
  144. Arthritis Rheumatol. 2016 Nov;68(11):2618-2628 - PubMed
  145. J Autoimmun. 2020 Jun;110:102392 - PubMed
  146. N Engl J Med. 1978 Apr 20;298(16):869-71 - PubMed
  147. Contemp Clin Trials. 2014 Sep;39(1):145-57 - PubMed
  148. Br J Anaesth. 2013 Jul;111(1):52-8 - PubMed
  149. Arthritis Rheum. 2010 Sep;62(9):2569-81 - PubMed
  150. Pain. 2003 Jul;104(1-2):201-8 - PubMed
  151. Nat Immunol. 2017 Jan;18(1):104-113 - PubMed
  152. J Glob Health. 2015 Jun;5(1):010409 - PubMed
  153. J Chem Neuroanat. 2008 Dec;36(3-4):216-26 - PubMed
  154. Nat Commun. 2016 Jun 10;7:11849 - PubMed
  155. J Neurosci Res. 1999 Sep 1;57(5):603-15 - PubMed
  156. Arthritis Rheum. 2002 Aug;47(4):391-7 - PubMed

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