Quad Sclavo Diagn. 1988 Jan-Dec;24(1):203-12.

[In vitro evaluation of the antibiotic effect of imipenen on bacterial strains isolated mostly from compromised patients].

Quaderni Sclavo di diagnostica clinica e di laboratorio

[Article in Italian]
M Bartolucci, F Galluzzi, G Sanchioni, G Aureli

PMID: 3268913

Abstract

The antibacterial activity in vitro of Imipenem (N-formimidoyl-thienamycin) was studied on 237 recently-isolated nosocomial bacterial strains and compared with Aztreonam, Cefotaxime, Ceftazidime, Ceftriaxone, Piperacillin, Amikacin and Netilmicin through the determination of susceptibility by the Kirby-Bauer method. Taking into account that 65% bacterial strains, out of the examined ones, came from antibiotic high-pressure departments (45% from bone-marrow transplanted patients in the Hematological Department and 20% from Intensive Care Unit patients), the results obtained in vitro show an activity of Imipenem on Gram-negative bacteria as much as a 92.7% susceptibility and a 75.7% on Gram-positive bacteria; when compared with the activity of the other antibiotics, Imipenem shows a really excellent activity.

Substances

• Imipenem

MeSH terms

• Drug Evaluation
• Gram-Negative Bacteria / drug effects
• Gram-Positive Bacteria / drug effects
• Humans
• Imipenem / pharmacology
• Immune Tolerance
• Microbial Sensitivity Tests

Publication Types

• Comparative Study
• English Abstract
• Journal Article