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Leysen L, Cools W, Nijs J, et al. The mediating effect of pain catastrophizing and perceived injustice in the relationship of pain on health-related quality of life in breast cancer survivors. Support Care Cancer. 2021;29(10):5653-5661doi: 10.1007/s00520-021-06011-4.
Leysen, L., Cools, W., Nijs, J., Adriaenssens, N., Pas, R., van Wilgen, C. P., Bults, R., Roose, E., Lahousse, A., & Beckwée, D. (2021). The mediating effect of pain catastrophizing and perceived injustice in the relationship of pain on health-related quality of life in breast cancer survivors. Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 29(10), 5653-5661. https://doi.org/10.1007/s00520-021-06011-4
Leysen, Laurence, et al. "The mediating effect of pain catastrophizing and perceived injustice in the relationship of pain on health-related quality of life in breast cancer survivors." Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer vol. 29,10 (2021): 5653-5661. doi: https://doi.org/10.1007/s00520-021-06011-4
Leysen L, Cools W, Nijs J, Adriaenssens N, Pas R, van Wilgen CP, Bults R, Roose E, Lahousse A, Beckwée D. The mediating effect of pain catastrophizing and perceived injustice in the relationship of pain on health-related quality of life in breast cancer survivors. Support Care Cancer. 2021 Oct;29(10):5653-5661. doi: 10.1007/s00520-021-06011-4. Epub 2021 Feb 10. PMID: 33569674.
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Support Care Cancer. 2021 Oct;29(10):5653-5661. doi: 10.1007/s00520-021-06011-4. Epub 2021 Feb 10.

The mediating effect of pain catastrophizing and perceived injustice in the relationship of pain on health-related quality of life in breast cancer survivors.

Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer

Laurence Leysen, Wilfried Cools, Jo Nijs, Nele Adriaenssens, Roselien Pas, C Paul van Wilgen, Rinske Bults, Eva Roose, Astrid Lahousse, David Beckwée

Affiliations

  1. Pain in Motion International Research Group, http://www.paininmotion.be, Brussels, Belgium. [email protected].
  2. Department of Physiotherapy, Human Physiology and Anatomy, Faculty of Physical Education and Physiotherapy, Vrije Universiteit Brussel, Building F-kine, Laarbeeklaan 103, BE-1090, Brussels, Belgium. [email protected].
  3. Interfaculty Center Data Processing and Statistics, Brussels Health Campus, Brussels, Belgium.
  4. Pain in Motion International Research Group, http://www.paininmotion.be, Brussels, Belgium.
  5. Department of Physiotherapy, Human Physiology and Anatomy, Faculty of Physical Education and Physiotherapy, Vrije Universiteit Brussel, Building F-kine, Laarbeeklaan 103, BE-1090, Brussels, Belgium.
  6. Department of Physical Medicine and Physiotherapy, University Hospital Brussels, Brussels, Belgium.
  7. Department of Oncology, University Hospital Brussels, Brussels, Belgium.
  8. Transcare Pijn - Transdisciplinary Pain Center, Groningen, the Netherlands.
  9. Department of Rehabilitation Sciences and Physiotherapy, Faculty of Physical Education and Physiotherapy, Vrije Universiteit Brussels, Brussels, Belgium.
  10. Department of Rehabilitation Sciences and Physiotherapy, Faculty of Medicine and Health Sciences, University of Antwerp, Wilrijk, Belgium.

PMID: 33569674 DOI: 10.1007/s00520-021-06011-4

Abstract

BACKGROUND: The importance of cognitive appraisals in the effectiveness of pain coping is well established. Two key variables in these appraisal processes are pain catastrophizing (PC) and perceived injustice (PI), which are known to increase the risk of long-term disability and aggravate the pain-related distress through maladaptive behavioral responses. However, to date, the mediating effects of these appraisals have not been examined concurrently in the breast cancer survivor (BCS) population, nor have they been related to health-related quality of life (HRQoL).

METHODS: Using cross-sectional data from 110 BCS, structural path analyses were used to examine the mediating effects of PC and PI in the relationship of pain on the HRQoL in BCS.

RESULTS: Results demonstrated a significant direct effect of pain and PI on HRQoL combined with a significant indirect effect through PI, but not through PC. An increase in pain is suggested to result in a decrease in quality of life. On the other hand, an increase in pain also is suggested to increase the PI. A similar relation with PC was not retained as significant.

CONCLUSION: The relative salience of PI as a mediator of HRQoL underscores the fact that PI is not only understudied but also underappreciated and undertreated in the BCS population. The results of our study warrant replication across longitudinal studies but continue to expand upon the evidence of the multifactorial nature of pain coping in BCS.

© 2021. The Author(s), under exclusive licence to Springer-Verlag GmbH, DE part of Springer Nature.

Keywords: Breast cancer survivors; Pain; Pain catastrophizing; Perceived injustice; Quality of life

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