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Rapp RS, Campbell RW, Howell JC, et al. Isoniazid hepatotoxicity in children. Am Rev Respir Dis. 1978;118(4):794-6doi: 10.1164/arrd.1978.118.4.794.
Rapp, R. S., Campbell, R. W., Howell, J. C., & Kendig, E. L. (1978). Isoniazid hepatotoxicity in children. The American review of respiratory disease, 118(4), 794-6. https://doi.org/10.1164/arrd.1978.118.4.794
Rapp, R S, et al. "Isoniazid hepatotoxicity in children." The American review of respiratory disease vol. 118,4 (1978): 794-6. doi: https://doi.org/10.1164/arrd.1978.118.4.794
Rapp RS, Campbell RW, Howell JC, Kendig EL. Isoniazid hepatotoxicity in children. Am Rev Respir Dis. 1978 Oct;118(4):794-6. doi: 10.1164/arrd.1978.118.4.794. PMID: 309296.
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Am Rev Respir Dis. 1978 Oct;118(4):794-6. doi: 10.1164/arrd.1978.118.4.794.

Isoniazid hepatotoxicity in children.

The American review of respiratory disease

R S Rapp, R W Campbell, J C Howell, E L Kendig

PMID: 309296 DOI: 10.1164/arrd.1978.118.4.794

Abstract

One hundred sixteen children, including 50 less than 10 years of age, received isoniazid therapy for tuberculous infection. Determinations of serum glutamic oxaloacetic transaminase concentrations at time of institution of therapy, 6 to 20 weeks later, and again at the completion of the therapeutic course, showed no evidence of hepatotoxicity. Clinical symptoms were never such that discontinuation of therapy was necessary.

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