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Wang D, Dan M, Ji Y, et al. Roles of ROS and cell cycle arrest in the genotoxicity induced by gold nanorod core/silver shell nanostructure. Nanoscale Res Lett. 2020;15(1):224doi: 10.1186/s11671-020-03455-1.
Wang, D., Dan, M., Ji, Y., Wu, X., Wang, X., & Wen, H. (2020). Roles of ROS and cell cycle arrest in the genotoxicity induced by gold nanorod core/silver shell nanostructure. Nanoscale research letters, 15(1), 224. https://doi.org/10.1186/s11671-020-03455-1
Wang, Dan, et al. "Roles of ROS and cell cycle arrest in the genotoxicity induced by gold nanorod core/silver shell nanostructure." Nanoscale research letters vol. 15,1 (2020): 224. doi: https://doi.org/10.1186/s11671-020-03455-1
Wang D, Dan M, Ji Y, Wu X, Wang X, Wen H. Roles of ROS and cell cycle arrest in the genotoxicity induced by gold nanorod core/silver shell nanostructure. Nanoscale Res Lett. 2020 Dec 07;15(1):224. doi: 10.1186/s11671-020-03455-1. PMID: 33284367; PMCID: PMC7721938.
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Nanoscale Res Lett. 2020 Dec 07;15(1):224. doi: 10.1186/s11671-020-03455-1.

Roles of ROS and cell cycle arrest in the genotoxicity induced by gold nanorod core/silver shell nanostructure.

Nanoscale research letters

Dan Wang, Mo Dan, Yinglu Ji, Xiaochun Wu, Xue Wang, Hairuo Wen

Affiliations

  1. Beijing Key Laboratory, National Center for Safety Evaluation of Drugs, National Institutes for Food and Drug Control, Beijing, 100176, People's Republic of China.
  2. China Pharmaceutical University, Nanjing, 211198, People's Republic of China.
  3. The State Key Laboratory of New Pharmaceutical Preparations and Excipients, 226 Huanghe Road, Shijiazhuang, 050035, Hebei, People's Republic of China.
  4. CAS Key Laboratory of Standardization and Measurement for Nanotechnology and CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology, Beijing, 100190, People's Republic of China.
  5. CAS Key Laboratory of Standardization and Measurement for Nanotechnology and CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology, Beijing, 100190, People's Republic of China. [email protected].
  6. Beijing Key Laboratory, National Center for Safety Evaluation of Drugs, National Institutes for Food and Drug Control, Beijing, 100176, People's Republic of China. [email protected].
  7. National Center for Safety Evaluation of Drugs, National Institutes for Food and Drug Control, Key Laboratory of Beijing for Nonclinical Safety Evaluation Research of Drugs, Beijing, 100176, People's Republic of China. [email protected].
  8. Beijing Key Laboratory, National Center for Safety Evaluation of Drugs, National Institutes for Food and Drug Control, Beijing, 100176, People's Republic of China. [email protected].
  9. National Center for Safety Evaluation of Drugs, National Institutes for Food and Drug Control, Key Laboratory of Beijing for Nonclinical Safety Evaluation Research of Drugs, Beijing, 100176, People's Republic of China. [email protected].

PMID: 33284367 PMCID: PMC7721938 DOI: 10.1186/s11671-020-03455-1

Abstract

To understand the genotoxicity induced in the liver by silver nanoparticles (AgNPs) and silver ions, an engineered gold nanorod core/silver shell nanostructure (Au@Ag NR) and humanized hepatocyte HepaRG cells were used in this study. The involvement of oxidative stress and cell cycle arrest in the DNA and chromosome damage induced by 0.4-20 µg mL

Keywords: Cell cycle arrest; Genotoxicity; Gold nanorod core/silver shell nanostructures; HepaRG cells; Oxidative stress; Silver ions

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