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Shaked Y, Samra Y, Zwas ST. Graves' disease presenting as pyrexia of unknown origin. Postgrad Med J. 1988;64(749):209-12doi: 10.1136/pgmj.64.749.209.
Shaked, Y., Samra, Y., & Zwas, S. T. (1988). Graves' disease presenting as pyrexia of unknown origin. Postgraduate medical journal, 64(749), 209-12. https://doi.org/10.1136/pgmj.64.749.209
Shaked, Y, et al. "Graves' disease presenting as pyrexia of unknown origin." Postgraduate medical journal vol. 64,749 (1988): 209-12. doi: https://doi.org/10.1136/pgmj.64.749.209
Shaked Y, Samra Y, Zwas ST. Graves' disease presenting as pyrexia of unknown origin. Postgrad Med J. 1988 Mar;64(749):209-12. doi: 10.1136/pgmj.64.749.209. PMID: 3050943; PMCID: PMC2428841.
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Postgrad Med J. 1988 Mar;64(749):209-12. doi: 10.1136/pgmj.64.749.209.

Graves' disease presenting as pyrexia of unknown origin.

Postgraduate medical journal

Y Shaked, Y Samra, S T Zwas

Affiliations

  1. Rusinow Department of Internal Medicine C, Chaim Sheba Medical Center,Tel-Hashomer, Israel.

PMID: 3050943 PMCID: PMC2428841 DOI: 10.1136/pgmj.64.749.209
Free PMC Article

Abstract

Fever is a common clinical manifestation of inflammatory processes of the thyroid and thyroid crisis. On the other hand, fever alone as a presenting symptom of thyrotoxicosis, without other manifestations, is extremely rare. A female patient is described in whom fever persisted for two months prior to hospitalization, but without clinical symptoms or signs to lead to suspicion of thyroid disease. After exhaustive investigation it was found that the patient was suffering from hyperthyroidism. Fever disappeared gradually on antithyroid therapy, recurred when the drugs were withdrawn for a rechallenge trial, and cleared up again after renewal. Four other cases of persistent fever as a presenting symptom of hyperthyroidism were found on a review of previous publications. Thyrotoxicosis should, therefore, be included in the differential diagnosis of pyrexia of unknown origin.

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