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Kanof ME, Strober W, Fiocchi C, et al. CD4 positive Leu-8 negative helper-inducer T cells predominate in the human intestinal lamina propria. J Immunol. 1988;141(9):3029-36
Kanof, M. E., Strober, W., Fiocchi, C., Zeitz, M., & James, S. P. (1988). CD4 positive Leu-8 negative helper-inducer T cells predominate in the human intestinal lamina propria. Journal of immunology (Baltimore, Md. : 1950), 141(9), 3029-36.
Kanof, M E, et al. "CD4 positive Leu-8 negative helper-inducer T cells predominate in the human intestinal lamina propria." Journal of immunology (Baltimore, Md. : 1950) vol. 141,9 (1988): 3029-36.
Kanof ME, Strober W, Fiocchi C, Zeitz M, James SP. CD4 positive Leu-8 negative helper-inducer T cells predominate in the human intestinal lamina propria. J Immunol. 1988 Nov 01;141(9):3029-36. PMID: 2902143.
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J Immunol. 1988 Nov 01;141(9):3029-36.

CD4 positive Leu-8 negative helper-inducer T cells predominate in the human intestinal lamina propria.

Journal of immunology (Baltimore, Md. : 1950)

M E Kanof, W Strober, C Fiocchi, M Zeitz, S P James

Affiliations

  1. Mucosal Immunity Section, National Institutes of Allergy and Infectious Diseases, Bethesda, MD 20892.

PMID: 2902143

Abstract

The regulatory function of peripheral blood CD4 T cells correlates with the presence or absence of the membrane glycoprotein recognized by anti-Leu-8 antibody; CD4,Leu8- T cells help Ig synthesis and CD4,Leu-8+ T cells suppress Ig synthesis. In contrast to CD4 T cells from the peripheral blood and organized gut-associated lymphoid tissues, intestinal lamina propria CD4 T cells were found to have diminished expression of the Leu-8 Ag. Therefore, studies were performed to determine whether the decreased expression of the Leu-8 Ag on lamina propria CD4 T cells correlates with a difference in the ability of peripheral blood and lamina propria CD4 T cells to regulate PWM-stimulated Ig synthesis. At high T cell to non-T cell ratios, the helper function of lamina propria CD4 T cells was significantly higher than that of peripheral blood CD4 T cells. When CD4 T cells were incubated with anti-Leu-8 antibody, the suppressor function of peripheral blood CD4 T cells was increased, but lamina propria CD4 T cells did not suppress Ig synthesis. No difference was found between the helper function of CD4,Leu-8- T cells and the suppressor function of CD4, Leu-8+ T cells isolated from either the peripheral blood or the lamina propria. Thus, the difference in the regulatory function of CD4 T cells from the peripheral blood and the lamina propria is due to the quantitative difference in CD4,Leu-8+ T cells in these sites. Consequently, the intestinal lamina propria is a site enriched in CD4,Leu-8- T cells which predominantly mediate help for Ig synthesis.

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