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Breuiller M, Rouot B, Leroy MJ, et al. Different alpha 2-adrenoceptor densities in the circular and longitudinal layers of human near-term myometrium as revealed by [3H]-idazoxan binding studies. Gynecol Obstet Invest. 1988;26(1):14-20doi: 10.1159/000293666.
Breuiller, M., Rouot, B., Leroy, M. J., Blot, P., & Ferré, F. (1988). Different alpha 2-adrenoceptor densities in the circular and longitudinal layers of human near-term myometrium as revealed by [3H]-idazoxan binding studies. Gynecologic and obstetric investigation, 26(1), 14-20. https://doi.org/10.1159/000293666
Breuiller, M, et al. "Different alpha 2-adrenoceptor densities in the circular and longitudinal layers of human near-term myometrium as revealed by [3H]-idazoxan binding studies." Gynecologic and obstetric investigation vol. 26,1 (1988): 14-20. doi: https://doi.org/10.1159/000293666
Breuiller M, Rouot B, Leroy MJ, Blot P, Ferré F. Different alpha 2-adrenoceptor densities in the circular and longitudinal layers of human near-term myometrium as revealed by [3H]-idazoxan binding studies. Gynecol Obstet Invest. 1988;26(1):14-20. doi: 10.1159/000293666. PMID: 2901998.
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S. Karger AG, Basel, Switzerland

Gynecol Obstet Invest. 1988;26(1):14-20. doi: 10.1159/000293666.

Different alpha 2-adrenoceptor densities in the circular and longitudinal layers of human near-term myometrium as revealed by [3H]-idazoxan binding studies.

Gynecologic and obstetric investigation

M Breuiller, B Rouot, M J Leroy, P Blot, F Ferré

Affiliations

  1. INSERM U.166, Maternité Baudelocque, Paris, France.

PMID: 2901998 DOI: 10.1159/000293666

Abstract

[3H]-idazoxan, a specific alpha 2-adrenoceptor antagonist radioligand, has been used to characterize alpha 2-adrenoceptors in both circular and longitudinal layers of human near-term myometrium. [3H]-idazoxan binding is reversible, saturable and stereospecific. It labels with high affinity a single population of sites. Competition curves with different alpha 2-adrenoceptor agonists and antagonists show that the binding sites labelled with [3H]-idazoxan have the pharmacological characteristics of alpha 2-adrenoceptors. Though the KD value is similar in both layers (approximately 7 nM), the density of alpha 2-adrenoceptors in the circular layer (324 +/- 21 fmol/mg of protein) is significantly higher than in the longitudinal one (183 +/- 48 fmol/mg of protein).

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