Display options
Cite
Simson PE, Cierpial MA, Heyneman LE, et al. Pertussis toxin blocks the effects of alpha 2-agonists and antagonists on locus coeruleus activity in vivo. Neurosci Lett. 1988;89(3):361-6doi: 10.1016/0304-3940(88)90553-8.
Simson, P. E., Cierpial, M. A., Heyneman, L. E., & Weiss, J. M. (1988). Pertussis toxin blocks the effects of alpha 2-agonists and antagonists on locus coeruleus activity in vivo. Neuroscience letters, 89(3), 361-6. https://doi.org/10.1016/0304-3940(88)90553-8
Simson, P E, et al. "Pertussis toxin blocks the effects of alpha 2-agonists and antagonists on locus coeruleus activity in vivo." Neuroscience letters vol. 89,3 (1988): 361-6. doi: https://doi.org/10.1016/0304-3940(88)90553-8
Simson PE, Cierpial MA, Heyneman LE, Weiss JM. Pertussis toxin blocks the effects of alpha 2-agonists and antagonists on locus coeruleus activity in vivo. Neurosci Lett. 1988 Jul 08;89(3):361-6. doi: 10.1016/0304-3940(88)90553-8. PMID: 2901703.
Copy Download .nbib Format: NLM
Share it on
Full text links
Elsevier Science

Neurosci Lett. 1988 Jul 08;89(3):361-6. doi: 10.1016/0304-3940(88)90553-8.

Pertussis toxin blocks the effects of alpha 2-agonists and antagonists on locus coeruleus activity in vivo.

Neuroscience letters

P E Simson, M A Cierpial, L E Heyneman, J M Weiss

Affiliations

  1. Department of Psychiatry, Duke University Medical Center, Durham, NC 27710.

PMID: 2901703 DOI: 10.1016/0304-3940(88)90553-8

Abstract

This study assessed the effects of pertussis toxin, which is known to inactivate G proteins and therefore to block receptors linked to G proteins, on electrophysiological activity of the locus coeruleus in vivo. Pertussis toxin was injected into the lateral cerebral ventricle of rats, and locus coeruleus activity was then recorded. Compared to vehicle-injected control animals, pretreatment with pertussis toxin markedly increased the spontaneous firing rate of locus coeruleus neurons. In addition, the alpha 2-antagonist idazoxan was no longer able to augment either spontaneous or evoked locus coeruleus activity after pretreatment with pertussis toxin. Finally, pretreatment with pertussis toxin made locus coeruleus neurons resistant to inhibition by the alpha 2-agonist clonidine. These results are consistent with the view that pertussis toxin blocks alpha 2-receptors, receptors linked to G proteins, in vivo.

Similar articles

Substances

MeSH terms

Publication Types

Grant support

LinkOut - more resources