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Bevilacqua M, Norbiato G, Vago T, et al. Alterations in norepinephrine content and beta adrenoceptor regulation in myocardium bordering aneurysm in human heart: their possible role in the genesis of ventricular tachycardia. Eur J Clin Invest. 1986;16(2):163-8doi: 10.1111/j.1365-2362.1986.tb01324.x.
Bevilacqua, M., Norbiato, G., Vago, T., Meroni, R., Dagani, R., Raggi, U., Frigeni, G., & Santoli, C. (1986). Alterations in norepinephrine content and beta adrenoceptor regulation in myocardium bordering aneurysm in human heart: their possible role in the genesis of ventricular tachycardia. European journal of clinical investigation, 16(2), 163-8. https://doi.org/10.1111/j.1365-2362.1986.tb01324.x
Bevilacqua, M, et al. "Alterations in norepinephrine content and beta adrenoceptor regulation in myocardium bordering aneurysm in human heart: their possible role in the genesis of ventricular tachycardia." European journal of clinical investigation vol. 16,2 (1986): 163-8. doi: https://doi.org/10.1111/j.1365-2362.1986.tb01324.x
Bevilacqua M, Norbiato G, Vago T, Meroni R, Dagani R, Raggi U, Frigeni G, Santoli C. Alterations in norepinephrine content and beta adrenoceptor regulation in myocardium bordering aneurysm in human heart: their possible role in the genesis of ventricular tachycardia. Eur J Clin Invest. 1986 Apr;16(2):163-8. doi: 10.1111/j.1365-2362.1986.tb01324.x. PMID: 3015633.
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Eur J Clin Invest. 1986 Apr;16(2):163-8. doi: 10.1111/j.1365-2362.1986.tb01324.x.

Alterations in norepinephrine content and beta adrenoceptor regulation in myocardium bordering aneurysm in human heart: their possible role in the genesis of ventricular tachycardia.

European journal of clinical investigation

M Bevilacqua, G Norbiato, T Vago, R Meroni, R Dagani, U Raggi, G Frigeni, C Santoli

PMID: 3015633 DOI: 10.1111/j.1365-2362.1986.tb01324.x

Abstract

On the assumption that alterations in the adrenergic system may play a role in generating ventricular tachycardia in patients with myocardial post-infarction apical aneurysm, we evaluated norepinephrine concentration, number and affinity of both beta 1 and beta 2 adrenoceptors in perianeurysmatic tissue in twelve patients operated upon for congestive heart failure and recurrent sustained ventricular tachycardia. Concentration of norepinephrine in perianeurysmatic tissue was 0.1 +/- 0.05 micrograms g-1 tissue (n = 8), this value being much lower than that found in papillary muscle (n = 10) from patients with mitral valve stenosis (0.8 +/- 0.02 micrograms g-1 tissue) (P less than 0.01). The total number of beta adrenoceptors (71.4 +/- 7.8 v. 48.0 +/- 5.1 fmol mg-1 protein; P less than 0.01) and the percentage of beta 1 subtype were found to be higher in perianeurysmatic tissue (approximately 90%) than in papillary muscle (approximately 68%). Out of twelve patients with aneurysm, beta 2 adrenoceptors had considerably decreased in three patients and were absent in the remaining nine. Decrease in the neuronally released norepinephrine associated with contrasting behaviours of beta 1 and beta 2 adrenoceptors suggests the presence of a profound alteration in the sympathetic innervation of the perianeurysmatic myocardial tissue that may contribute to the genesis of sustained ventricular tachycardia in patients with postinfarction apical aneurysm.

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