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Spurr NK, Gough AC, Gosden J, et al. Restriction fragment length polymorphism analysis and assignment of the metalloproteinases stromelysin and collagenase to the long arm of chromosome 11. Genomics. 1988;2(2):119-27doi: 10.1016/0888-7543(88)90093-6.
Spurr, N. K., Gough, A. C., Gosden, J., Rout, D., Porteous, D. J., van Heyningen, V., & Docherty, A. J. (1988). Restriction fragment length polymorphism analysis and assignment of the metalloproteinases stromelysin and collagenase to the long arm of chromosome 11. Genomics, 2(2), 119-27. https://doi.org/10.1016/0888-7543(88)90093-6
Spurr, N K, et al. "Restriction fragment length polymorphism analysis and assignment of the metalloproteinases stromelysin and collagenase to the long arm of chromosome 11." Genomics vol. 2,2 (1988): 119-27. doi: https://doi.org/10.1016/0888-7543(88)90093-6
Spurr NK, Gough AC, Gosden J, Rout D, Porteous DJ, van Heyningen V, Docherty AJ. Restriction fragment length polymorphism analysis and assignment of the metalloproteinases stromelysin and collagenase to the long arm of chromosome 11. Genomics. 1988 Feb;2(2):119-27. doi: 10.1016/0888-7543(88)90093-6. PMID: 2900807.
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Elsevier Science

Genomics. 1988 Feb;2(2):119-27. doi: 10.1016/0888-7543(88)90093-6.

Restriction fragment length polymorphism analysis and assignment of the metalloproteinases stromelysin and collagenase to the long arm of chromosome 11.

Genomics

N K Spurr, A C Gough, J Gosden, D Rout, D J Porteous, V van Heyningen, A J Docherty

Affiliations

  1. Imperial Cancer Research Fund, Clare Hall Laboratories, South Mimms, Herts, United Kingdom.

PMID: 2900807 DOI: 10.1016/0888-7543(88)90093-6

Abstract

Collagenase and stromelysin are two metalloproteinases produced mainly by connective tissue cells and involved in the breakdown of the extracellular matrix. cDNA clones for both of these genes have been isolated and sequencing has shown them to be closely related. The collagenase and stromeylsin cDNA clones have been used to assign these genes to the long arm of chromosome 11 in the regions 11q21-22.1 and 11q22.2-22.3, respectively. This has been achieved using somatic cell hybrids and in situ hybridization. In addition a Taq1 restriction fragment length polymorphism has been demonstrated using the stromelysin cDNA.

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