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Doelman CJ, Kramer K, Timmerman H, et al. Vitamin E and selenium regulate balance between beta-adrenergic and muscarinic responses in rat lungs. FEBS Lett. 1988;233(2):427-31doi: 10.1016/0014-5793(88)80476-9.
Doelman, C. J., Kramer, K., Timmerman, H., & Bast, A. (1988). Vitamin E and selenium regulate balance between beta-adrenergic and muscarinic responses in rat lungs. FEBS letters, 233(2), 427-31. https://doi.org/10.1016/0014-5793(88)80476-9
Doelman, C J, et al. "Vitamin E and selenium regulate balance between beta-adrenergic and muscarinic responses in rat lungs." FEBS letters vol. 233,2 (1988): 427-31. doi: https://doi.org/10.1016/0014-5793(88)80476-9
Doelman CJ, Kramer K, Timmerman H, Bast A. Vitamin E and selenium regulate balance between beta-adrenergic and muscarinic responses in rat lungs. FEBS Lett. 1988 Jun 20;233(2):427-31. doi: 10.1016/0014-5793(88)80476-9. PMID: 2838338.
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FEBS Lett. 1988 Jun 20;233(2):427-31. doi: 10.1016/0014-5793(88)80476-9.

Vitamin E and selenium regulate balance between beta-adrenergic and muscarinic responses in rat lungs.

FEBS letters

C J Doelman, K Kramer, H Timmerman, A Bast

Affiliations

  1. Dept of Pharmacochemistry, Faculty of Chemistry, Vrije Universiteit, Amsterdam, The Netherlands.

PMID: 2838338 DOI: 10.1016/0014-5793(88)80476-9
Free Article

Abstract

The effects of hydrogen peroxide on the beta-adrenergic and muscarinic responses of the rat trachea muscle were studied in vitro, after feeding rats, for 6 weeks, either a diet deficient in vitamin E and selenium or a control diet. In the control situation after incubation with 1 mM hydrogen peroxide for 30 min, a reduction of the maximal response to methacholine of 39% occurred whereas no pD2 shift could be demonstrated. Moreover, no response to isoprenaline after precontraction with 3 x 10(-7) M methacholine was left. In the deficient situation, we found a reduction to 64% of the response to methacholine after incubation with 1 mM hydrogen peroxide. Again isoprenaline became inactive, i.e. no relaxation with isoprenaline was observed after precontraction with 3 x 10(-7) M methacholine. We therefore conclude that vitamin E and selenium protect against oxidative stress in lung tissue and thus regulate the (patho-) physiological balance between adrenergic and muscarinic responses.

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