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Weber DJ, Rutala WA, Samsa GP, et al. Obesity as a predictor of poor antibody response to hepatitis B plasma vaccine. JAMA. 1985;254(22):3187-9
Weber, D. J., Rutala, W. A., Samsa, G. P., Santimaw, J. E., & Lemon, S. M. (1985). Obesity as a predictor of poor antibody response to hepatitis B plasma vaccine. JAMA, 254(22), 3187-9.
Weber, D J, et al. "Obesity as a predictor of poor antibody response to hepatitis B plasma vaccine." JAMA vol. 254,22 (1985): 3187-9.
Weber DJ, Rutala WA, Samsa GP, Santimaw JE, Lemon SM. Obesity as a predictor of poor antibody response to hepatitis B plasma vaccine. JAMA. 1985 Dec 13;254(22):3187-9. PMID: 2933532.
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JAMA. 1985 Dec 13;254(22):3187-9.

Obesity as a predictor of poor antibody response to hepatitis B plasma vaccine.

JAMA

D J Weber, W A Rutala, G P Samsa, J E Santimaw, S M Lemon

PMID: 2933532

Abstract

Factors associated with lack of antibody response to the hepatitis B virus plasma vaccine were retrospectively evaluated by means of a logistic regression in 194 previously seronegative staff members of a community hospital. All subjects had received three doses of vaccine by intramuscular buttock injection using a 1-in, 23-gauge needle. Overall, only 55.7% of subjects developed detectable antibody to hepatitis B surface antigen in serum after immunization. The weight-height index served as a surrogate measure of obesity. Predictors of poor immunogenic response to hepatitis B vaccine included higher weight-height index, older age, and vaccine batch. Sex, race, timing of vaccine doses, and timing of postimmunization determination of antibody to hepatitis B surface antigen were not predictors of vaccine efficacy.

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